CORE--TECHNICAL RESOURCES

核心--技术资源

• 批准号: 6106196
• 负责人: JOHN C LOPER
• 金额: $ 17.11万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6106196
• 关键词: analytical chemistry; behavioral /social science research tag; biomedical facility; biotransformation; environmental toxicology; information dissemination; mass spectrometry

The mission of the TRC is to provide for analyses of quality in the interdisciplinary aspects of the Program, and to provide for methods development for new research areas and in interactions for technology transfer to industry. The equipment component assists in providing basic equipment necessary for individual project research, and for equipment needed for interdisciplinary multiproject research. Research in the program has pointed to the potential application of the methods and results to current questions of environmental hazards that are presented by industry-wide problems. A common issue is the question of the environmental stability, persistence and fate of apparently recalcitrant compounds and the impact of these compounds on human health. The primary TRC project examines whether components of metal-complex azo dyes become bioavailable and thus a threat to human health. Five metal-complex dyes in commercial use will be examined for the constituents of the starting press cake dyes, their organic portions, potential degradation products and free ionic metals. Environmental samples will be press cake from the manufactures, wastewater treatment products, sludges and effluents from textile dye users, and water and sediment samples upstream and downstream from effluent discharges. Analyses will involve HPLC and inductively coupled plasma/mass spectrometry for metal speciation, chemical stability under abiotic and biotic conditions, environmental partition properties and the biological stability of the dyes. Long range goals include biofilm reactor studies of these samples and of environmental samples from other metal producing and using industries.

真相与和解委员会的使命是提供对 该计划的跨学科方面，并提供方法 新研究领域的发展和技术的相互作用 转移到工业。 设备组件有助于提供基本的 个别项目研究所需的设备，以及 需要进行跨学科的多项目研究。 的研究 该计划指出了这些方法的潜在应用， 结果，以目前的问题，环境危害， 全行业的问题。 一个共同的问题是 环境的稳定性、持久性和明显退化的 化合物以及这些化合物对人类健康的影响。 主 TRC项目研究金属络合偶氮染料的成分是否会成为 生物可利用性，因此对人类健康构成威胁。 五种金属络合物染料 在商业使用中，将检查起始成分 滤饼染料、其有机部分、潜在降解产物 和游离离子金属。 环境样本将是来自 制造业、废水处理产品、污泥和废水 纺织品染料用户，以及上游和下游的水和沉积物样本 从污水排放。 分析将涉及HPLC和电感 用于金属形态、化学稳定性的耦合等离子体/质谱法 在非生物和生物条件下， 以及染料的生物稳定性。 长期目标包括 这些样品和环境样品的生物膜反应器研究 从其他金属生产和使用行业。