Testing repeatability in the evolution of complex traits: the genetics of convergent structural colour

测试复杂性状进化的可重复性：趋同结构色的遗传学

• 批准号: NE/K008498/1
• 负责人: Nicola Nadeau
• 金额: $ 82.02万
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=NE%2FK008498%2F1
• 关键词: Testing; repeatability; evolution; complex; traits

How repeatable is the evolutionary process and would the same evolutionary pathways always be used to reach a given end-point? Recent work on the genes responsible for adaptation in the wild suggests that certain genes are particularly likely to be the target of selection. This may be because these genes have large effects on the traits under selection without having effects on other traits. However, some adaptive differences are due to the combined effects of many genes. In these cases it is less clear how repeatable the evolutionary process will be and if the same sets of genes will be used when evolving similar traits. Organisms that that have converged on similar phenotypes can help us to answer these questions because they represent independent evolutionary trajectories towards the same endpoint.The Heliconius butterflies are one of the most striking examples of evolutionary convergence. They have bright colour patterns that warn predators of their distastefulness and several species have converged on near identical colour patterns. This reduces the number of patterns that predators have to learn, so benefitting all individuals that share them. This provides a "natural experiment" in which to test whether the same genes are used when evolving the same phenotypes. Results from this system have shown that the same major switch genes have independently been used in two species to produce the same colour patterns. However, these genes do not explain all of the evolutionary changes. Some populations of these two species have evolved an iridescent blue colour, which is controlled by many genes. I will identify what these genes are and if they are the same or different between species. If the same genes have been independently used in both species it will suggest that evolution is predictable, so when evolving a certain trait a particular set of genes are likely to always be used. On the other hand if different genes are used then it will suggest that traits that are controlled by multiple genes are more flexible in their evolution. Given that many important traits are controlled by large numbers of genes, such as size and behaviour, this has important implications for our understanding of the evolutionary process. If evolution can proceed down multiple routes in order to arrive at the same endpoint, then it is likely to be easier and faster than if it is constrained to use particular genes. Iridescent colours like those of the peacock and blue morpho butterfly are some of the most spectacular in the animal kingdom. They are produced by sub-micron-scale structures that cause coherent scattering of light, rather than the absorption of light by pigments. Although these types of colours are often used in animal signalling, nothing is currently known about the genes controlling them. Identifying the genes responsible for controlling these colours in Heliconius will shed some light on the genetics and development of these traits and provide candidate genes for their control in other systems. There is commercial interest in replicating these types of colours artificially, for use in anticounterfeiting and advanced materials technologies. If the genetic basis of these traits can be understood, this will be an important step towards understanding how such structures are assembled in natural systems, which will allow the problem of how to synthesise materials with similar properties to be approached from an entirely new angle.

进化过程的可重复性如何？是否总是使用相同的进化途径来达到给定的终点？最近对负责野外适应的基因的研究表明，某些基因特别可能成为选择的目标。这可能是因为这些基因对选择中的性状有很大的影响，而对其他性状没有影响。然而，一些适应性差异是由于许多基因的综合作用。在这些情况下，我们不太清楚进化过程的可重复性如何，以及在进化相似性状时是否使用相同的基因组。具有相似表型的生物体可以帮助我们回答这些问题，因为它们代表了朝向同一终点的独立进化轨迹。Heliconius蝴蝶是进化趋同的最引人注目的例子之一。它们有明亮的颜色图案，警告捕食者它们的厌恶，几个物种已经聚集在几乎相同的颜色图案上。这减少了捕食者必须学习的模式的数量，从而使所有分享它们的个体受益。这提供了一个“自然实验”，以测试在进化相同的表型时是否使用相同的基因。该系统的结果表明，相同的主要开关基因已独立地用于两个物种，以产生相同的颜色模式。然而，这些基因并不能解释所有的进化变化。这两个物种的一些种群进化出了彩虹色的蓝色，这是由许多基因控制的。我将确定这些基因是什么，以及它们在物种之间是相同还是不同。如果相同的基因在两个物种中被独立使用，这将表明进化是可预测的，因此当进化某个特征时，可能总是使用一组特定的基因。另一方面，如果使用不同的基因，那么它将表明由多个基因控制的性状在进化中更灵活。考虑到许多重要的性状是由大量的基因控制的，如大小和行为，这对我们理解进化过程具有重要意义。如果进化可以沿着多条路线进行，以达到同一个终点，那么它可能比限制使用特定基因更容易和更快。像孔雀和蓝闪蝶一样的彩虹色是动物王国中最壮观的颜色。它们是由亚微米级的结构产生的，这种结构会引起光的相干散射，而不是色素对光的吸收。虽然这些类型的颜色经常用于动物信号，但目前对控制它们的基因一无所知。确定Heliconius中负责控制这些颜色的基因将有助于了解这些性状的遗传和发展，并为其他系统中的控制提供候选基因。人工复制这些类型的颜色，用于防伪和先进的材料技术，具有商业利益。如果能够理解这些特征的遗传基础，这将是理解这些结构如何在自然系统中组装的重要一步，这将允许从一个全新的角度来处理如何合成具有相似性质的材料的问题。

项目成果

The genetic basis of structural colour variation in mimetic Heliconius butterflies.

• DOI: 10.1098/rstb.2020.0505
• 发表时间: 2022-07-18
• 期刊: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
• 影响因子: 6.3
• 作者: Brien, Melanie N.;Enciso-Romero, Juan;Lloyd, Victoria J.;Curran, Emma V.;Parnell, Andrew J.;Morochz, Carlos;Salazar, Patricio A.;Rastas, Pasi;Zinn, Thomas;Nadeau, Nicola J.
• 通讯作者: Nadeau, Nicola J.

The role of composition: natural materials vs. synthetic composites: general discussion.

成分的作用：天然材料与合成复合材料：一般讨论。

• DOI: 10.1039/d0fd90017f
• 发表时间: 2020
• 期刊: Faraday discussions
• 影响因子: 3.4
• 作者: Bermudez Ureña E

Figure S1 and Figure S2: from Phenotypic variation in

图S1和图S2：来自表型变异

• DOI: 10.6084/m9.figshare.7346231
• 发表时间: 2018
• 作者: Brien M

Optics and photonics in nature: general discussion.

自然界中的光学和光子学：一般讨论。

• DOI: 10.1039/d0fd90013c
• 发表时间: 2020
• 期刊: Faraday discussions
• 影响因子: 3.4
• 作者: Arwin H

Müllerian mimicry of a quantitative trait despite contrasting levels of genomic divergence and selection

尽管基因组分歧和选择水平不同，但数量性状的缪勒拟态

• DOI: 10.1101/842708
• 发表时间: 2019
• 作者: Curran E