STRUCTURAL EVOLUTION OF PRIMATE BRAIN

本项目建立了一个比较数据库 灵长类的高分辨磁共振神经解剖学研究 成像(MRI)。总共对44只动物进行了扫描，包括 上面列出的每个物种的代表和所有这些扫描 已重建以提供表面渲染和体积 措施。这些扫描的数字化版本已存储在 分发给对灵长类感兴趣的研究人员的光盘 大脑进化。我们自己的分析表明：1) 与类人猿相比，人类的相对小脑体积；2)减少 在人脑中的相对胼胝体大小；3)亲属 人类大脑半球内投射的增加。这些 研究为比较研究提供了第一个MRI数据库 灵长类动物的大脑进化，应该会对 人类与非人类灵长类神经解剖学的差异。资金来源 麦克阿瑟基金会$40,000 9/01/96-2/28/98利基基金会$ 7,500 1/1/97-12/31/99 Ring，J.K.和Insel，T.R. 灵长类动物脑内神经投射系统的差异扩展 进化论。神经报告(印刷中)。里林，J.K.和英塞尔，T.R. 灵长类动物小脑的进化相对体积差异 在猴子、猿类和人类之间。大脑、行为和进化 52：308-314,1998。瑞林和英塞尔，灵长类新皮质 在比较的角度下，使用磁共振成像。人类 进化(正在印刷中)。P51RR00165-38 1998年1月1日-1998年12月31日耶克斯地区 灵长类研究中心

This project has established a database for comparative neuroanatomy of primates using high resolution magnetic resonance imaging (MRI). A total of 44 animals were scanned, including representatives of every species listed above and all of these scans have been reconstructed to provide surface rendering and volumetric measures. Digitized versions of these scans have been stored on compact disc for distribution to investigators interested in primate brain evolution. Our own analysis has demonstrated 1) a decrease in relative cerebellar volume in humans compared to apes; 2) a decrease in relative corpus callosum size in the human brain; and 3) a relative increase in intra-hemispheric projections in the human brain. These studies provide the first MRI database for studies of comparative primate brain evolution and should yield novel insights into differences between human and non-human primate neuroanatomy. FUNDING MacArthur Foundation $40,000 9/01/96 - 2/28/98 Leakey Foundation $ 7,500 1/01/97 - 12/31/99 PUBLICATIONS Rilling, J.K. and Insel, T.R. Differential expansion of neural projection systems in primate brain evolution. NeuroReport (In press). Rilling, J.K. and Insel, T.R. Evolution of the cerebellum in primates Differences in relative volume among monkeys, apes, and humans. Brain, Behavior and Evolution 52:308-314, 1998. Rilling, J.K. and Insel, T.R. The primate neocortex in comparative perspective using magnetic resonance imaging. Human Evolution (In press). P51RR00165-38 1/1/98 - 12/31/98 Yerkes Regional Primate Research Center