STRUCTURAL EVOLUTION OF PRIMATE BRAIN

灵长类动物大脑的结构进化

• 批准号: 6277493
• 负责人: Thomas R. Insel
• 金额: $ 4.01万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6277493
• 关键词: Mammalia; Primates; cognition; magnetic resonance imaging; nervous system; psychology; sociology /anthropology; technology /technique

The goal of this project is to establish a database for comparative neuroanatomy of primates using high resolution magnetic resonance imaging (MRI). Thus far, 44 animals have been scanned, including representatives of every species listed above and all of these scans have been reconstructed to provide surface rendering and volumetric measures of whole brain and whole cerebellum. A technique for gray matter/white matter segmentation has been developed and applied to analyze these volumes separately. Results to date indicate 1) a decrease in relative cerebellar volume in humans compared to apes; 2) a decrease in relative corpus callosum size in the human brain; and 3) marked regional expansion of neocortex in the human and ape brains as measured by gyrification. These studies provide the first MRI database for studies of comparative primate brain evolution and should yield novel insights into differences between human and non-human primate neuroanatomy.

该项目的目标是建立一个数据库， 用高分辨率磁共振技术对灵长类动物进行比较神经解剖学研究 磁共振成像（MRI）。 到目前为止，已经扫描了44只动物， 包括上面列出的每一个物种的代表和所有 这些扫描已经被重建以提供表面再现， 整个大脑和整个小脑的体积测量。 一种技术 对于灰质/白色物质分割已经开发， 分别对这些卷进行分析。 迄今为止的结果表明， 1)人类小脑相对体积的减少， 猿类; 2）人类胼胝体相对大小的减少 大脑;以及3）人类新皮层的显著区域扩张， 通过脑回化来测量猿类大脑。 这些研究提供了 第一个用于比较灵长类动物大脑进化研究的MRI数据库 并应该产生新的见解之间的差异人类和 非人类灵长类神经解剖学