ACTION OF GROWTH HORMONE ANALOGUES IN PRIMATES

生长激素类似物在灵长类动物中的作用

• 批准号: 6288140
• 负责人: MARK E WILSON
• 金额: $ 8.4万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6288140
• 关键词: Mammalia; endocrine gland /system; growth /development; hormones; model design /development

This project evaluated the efficacy of two doses of 4 different formulations of a growth hormone receptor antagonist currently under being examined for the treatment of acromegaly. Efficacy was determined by the ability of the drug to suppress serum concentrations of insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP) -3. The results of this study provided significant new information for the advancing a successful treatment regimen in acromegalics. In addition, these studies provide new information for the development of an animal model of GH receptor deficiency that could be used to study growth and development. FUNDING Sensus Drug Development Corp. $35,200 07/01/98 - 6/30/99 PUBLICATIONS None P51RR00165-38 1/1/98 - 12/31/98 Yerkes Regional Primate Research Center

该项目评估了两种剂量的4种不同药物的疗效 目前正在研发的生长激素受体拮抗剂的配方 正在接受肢端肥大症的治疗检查。功效是 由药物抑制血清浓度的能力决定 胰岛素样生长因子-I和胰岛素样生长因子结合蛋白 -3.这项研究的结果提供了重要的新信息 为推进肢端肥大症的成功治疗方案而努力。在……里面 此外，这些研究还为开发 一种可用于研究生长激素受体缺陷的动物模型 成长和发展。资助人口普查药物开发公司35,200美元 07/01/98-6/30/99出版物无P51RR00165-38 1/1/98-12/31/98 耶尔基斯地区灵长类研究中心