NEUTROPHIL FUNCTION IN SEVERE PERIODONTITIS SUBJECTS
严重牙周炎患者的中性粒细胞功能
基本信息
- 批准号:6238375
- 负责人:
- 金额:$ 4.85万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-08-01 至 2000-04-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The neutrophil plays a key role in host defense against infection due to
extracellular bacteria. Considerable evidence also indicates that the
neutrophil is a critical element of host defense against periodontal
injury initiated by bacteria in dental plaque. In order to provide such
defense, adequate numbers of neutrophils must first penetrate vascular
endothelium through an adhesion-dependent process. Following extra-
vasation, neutrophils must migrate toward, ingest and ultimately destroy
the target bacteria. Defects in neutrophil production or function often
result in increased susceptibility to recurrent bacterial infection, and
appear to predispose to early-onset, severe forms of periodontal disease
which may arise prior to or during puberty.
Susceptibility to severe periodontitis varies widely in the adult
population. Cross-sectional studies conducted at the Clinical Research
Center have identified certain variables associated with increased risk
of severe periodontitis. Included in this group of "risk indicators" are
diabetes and smoking. A key objective of studies proposed in this
Clinical Research Center application is to conduct longitudinal studies
necessary to establish if diabetes and/or smoking constitute true "risk
factors" for development of severe periodontitis. Diabetes has long been
associated with increased susceptibility to infection, attributable in
part to altered neutrophil function. Neutrophil adherence, chemotaxis,
phagocytosis and killing are often decreased in diabetes. Vascular
changes observed in diabetes may also impede neutrophil extravasation
into infected tissues. Various components of tobacco smoke have also
been reported to inhibit neutrophil function.
The objective of this pilot study is to determine whether apparent
increases in susceptibility to periodontitis seen in diabetics or smokers
are associated with impaired neutrophil function. Specific parameters
to be evaluated will include a) in situ crevicular leukocyte responses
to casein, b) expression of cell adhesion molecules (Mac-1/CR3, L-
selectin) using anti-adhesion monoclonal antibodies in conjunction with
flow cytometric techniques, c) in vitro aerobic and anaerobic
bactericidal activity toward Actinobacillus actinomycetemcomitans, d)
neutrophil degranulation, as determined by flow cytometric analysis of
right angle light scatter, and e) chemotaxin (IL-8, fMLP)-induced signal
transduction (IP3 production). Neutrophil responses will be compared in
a) diabetic vs. non-diabetic periodontitis patients (balanced for
smoking, microflora and age), b) smoker vs. non-smoker periodontitis
patients (non-diabetic only balanced for microflora and age), and c)
periodontitis subjects vs. periodontally healthy (diabetic and non-
diabetic, as well as smoker and non-smoker) controls. These pilot
studies are designed to provide the basis for an in-depth assessment of
mechanisms by which smoking and/or diabetes impairs neutrophil-mediated
defenses.
中性粒细胞在宿主防御感染中起关键作用
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MARK E WILSON其他文献
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{{ truncateString('MARK E WILSON', 18)}}的其他基金
ACTION OF GROWTH HORMONE ANALOGUES IN PRIMATES
生长激素类似物在灵长类动物中的作用
- 批准号:
6593891 - 财政年份:2002
- 资助金额:
$ 4.85万 - 项目类别:
GROWTH REGULATION OF THE NEUROBIOLOGY OF PUBERTY
青春期神经生物学的生长调节
- 批准号:
6526349 - 财政年份:2000
- 资助金额:
$ 4.85万 - 项目类别:
GROWTH REGULATION OF THE NEUROBIOLOGY OF PUBERTY
青春期神经生物学的生长调节
- 批准号:
6197468 - 财政年份:2000
- 资助金额:
$ 4.85万 - 项目类别:
GROWTH REGULATION OF THE NEUROBIOLOGY OF PUBERTY
青春期神经生物学的生长调节
- 批准号:
6388091 - 财政年份:2000
- 资助金额:
$ 4.85万 - 项目类别:
GROWTH REGULATION OF THE NEUROBIOLOGY OF PUBERTY
青春期神经生物学的生长调节
- 批准号:
6603396 - 财政年份:2000
- 资助金额:
$ 4.85万 - 项目类别:
ACTION OF GROWTH HORMONE ANALOGUES IN PRIMATES
生长激素类似物在灵长类动物中的作用
- 批准号:
6288140 - 财政年份:1999
- 资助金额:
$ 4.85万 - 项目类别:
ORAL IMMUNOLOGY/MICROBIOLOGY RESEARCH GROUP MEETING
口腔免疫学/微生物学研究组会议
- 批准号:
2564696 - 财政年份:1998
- 资助金额:
$ 4.85万 - 项目类别:
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