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GENETICS OF AUTISTIC DISORDER

GENETICS OF AUTISTIC DISORDER
自闭症的遗传学
批准号：
6108860
负责人：
M Anne Spence
金额：
$21.96万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-03-01 至 2000-02-29
来源：
https://reporter.nih.gov/project-details/6108860
关键词：
adrenocorticotropic hormone autism behavior test blood chemistry chromosome disorders clinical research computer system design /evaluation cytogenetics denaturing gradient gel electrophoresis family genetics gene expression gene frequency genetic markers genetic polymorphism human genetic material tag human subject linkage mapping magnetic resonance imaging mental disorder diagnosis mental health information system middle childhood (6-11) phenotype polymerase chain reaction preschool child (1-5) proopiomelanocortin

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Description (Adapted from applicant's description): The goal of this project is to identify distinct subtypes of autism disorder and to map the loci biological or behavioral differences (neurobiological phenotypes) among patients diagnosed with AD. For stable differences they will study first-degree relatives to establish the trait is familial and to identify genetic patterns of transmission. Then they will apply linkage and association tests to an appropriate series of genome DNA markers. GRANT =P01HD354580002 Description(Adapted from the applicant's description): To further investigate the anomalous neural systems in autistic disorder as a phenotype for genetic analysis, the investigators will perform high- resolution three-dimensional magnetic resonance imaging (MRI) scans in two childhood AD populations as the basis for subsequent complete morphometric analysis for computation of volume of whole brain, individual substructures, hemispheric regions, and application of specialized method of cortical localization and parcellation.
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Core--Genetics
GENETICS OF AUTISTIC DISORDER
GENETICS OF AUTISTIC DISORDER
GENETICS OF AUTISTIC DISORDER
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