GENETICS OF AUTISTIC DISORDER

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the project, "The Neurobiology and Genetics of Autism", is to learn more about the cause(s) of Autistic Disorder (AD). The Assessment Core serves as the data collection hub for the project. As part of this, study participants undergo an initial assessment that includes the Autism Diagnostic Observation Schedule (ADOS) and the Autism Diagnostic Interview (ADI) to determine study eligibility. Following, they will undergo tests of intelligence, academic achievement, executive function, and language and communication function. A full genetics evaluation will be completed, which will include a clinical examination, an extensive family history (pedigree), and a blood sample for future attempts to identify the gene(s) that may play a role in autism. In addition to the above, "The Neurobiology and Genetics of Autism" is composed of two other projects. Project 2, MRI, is designed to determine the changes in brain structure using MRI scans for children diagnosed with AD. Project 3, Regression, studies the phenomenon of lost developmental milestones in children with autism by viewing videotape records of the children's development during the first two years of life.