SAFETY AND EFFICACY OF INHALED CORTICOSTEROIDS IN CHILDREN WITH CYSTIC FIBROSIS

吸入皮质类固醇治疗囊性纤维化儿童的安全性和有效性

• 批准号: 6114956
• 负责人: Frank J. Accurso
• 金额: $ 1.99万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6114956
• 关键词: child (0-11); clinical research; corticosteroids; cystic fibrosis; drug screening /evaluation; hormone therapy; human subject; human therapy evaluation; inflammation; inhalation drug administration; respiratory disorder chemotherapy

Airway disease in CF is characterized by neutrophil-dominated inflammation. Treatment with inhaled corticosteroids has resulted in decreased airway inflammation in other lung diseases. The aim of this protocol is to determine safety and efficacy of inhaled corticosteroids in children with CF. Two studies have been completed looking a Beclovent and Fluticasone. In the Beclovent study, mild adrenal suppression was noted as with the Fluticasone study also. In the Beclovent study, there seemed to be an effect on airway inflammation, but the Fluticasone study did not find this.

慢性阻塞性肺疾病的特点是以中性粒细胞为主的炎症。吸入糖皮质激素治疗可减少其他肺部疾病的呼吸道炎症。该方案的目的是确定吸入糖皮质激素治疗儿童CF的安全性和有效性。目前已经完成了两项研究，分别是贝氯特和氟替卡松。在贝考特的研究中，与氟替卡松的研究一样，也注意到轻微的肾上腺抑制。在贝考特的研究中，似乎对呼吸道炎症有影响，但氟替卡松的研究没有发现这一点。