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SAFETY AND EFFICACY OF INHALED CORTICOSTEROIDS IN CHILDREN WITH CYSTIC FIBROSIS

SAFETY AND EFFICACY OF INHALED CORTICOSTEROIDS IN CHILDREN WITH CYSTIC FIBROSIS
吸入皮质类固醇治疗囊性纤维化儿童的安全性和有效性
批准号：
6114956
负责人：
Frank J. Accurso
金额：
$1.99万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6114956
关键词：
child (0-11) clinical research corticosteroids cystic fibrosis drug screening /evaluation hormone therapy human subject human therapy evaluation inflammation inhalation drug administration respiratory disorder chemotherapy

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英文摘要
Airway disease in CF is characterized by neutrophil-dominated inflammation. Treatment with inhaled corticosteroids has resulted in decreased airway inflammation in other lung diseases. The aim of this protocol is to determine safety and efficacy of inhaled corticosteroids in children with CF. Two studies have been completed looking a Beclovent and Fluticasone. In the Beclovent study, mild adrenal suppression was noted as with the Fluticasone study also. In the Beclovent study, there seemed to be an effect on airway inflammation, but the Fluticasone study did not find this.
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    Frank J. Accurso
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    UNIVERSITY OF COLORADO DENVER
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    $0.37万
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    UNIVERSITY OF COLORADO DENVER
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    2007
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    Frank J. Accurso
  • 依托单位：
    UNIVERSITY OF COLORADO DENVER
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