ACTG 247:INCREASED CALORIC FORMULA EFFECT ON GROWTH & NUTRITION ON HUM INFANTS

本试验旨在评估浓缩婴儿配方奶粉与标准婴儿配方奶粉相比对HIV感染婴儿体重增加、生长和营养状况的影响。 主要的具体目标是确定在出生后14天内开始的艾滋病毒感染婴儿的热量补充是否会改善28周时的体重或身长增长。 第二个具体目标是a）确定营养补充对头围的影响，头围是大脑生长、免疫状态、机会性感染的指标;和生活质量，和B）评价长期耐受性在HIV感染婴儿中，浓缩配方奶粉与标准配方奶粉的短期耐受性（28周）比较与标准配方奶粉相比，浓缩配方奶粉在所有艾滋病毒暴露婴儿中的作用。

This trial is designed to evaluate the effect of concentrated infant formula compared with standard infant formula on weight gain, growth and nutritional status in HIV-infected infants. The primary specific aim is to determine if caloric supplementation in HIV-infected infants, started within the first 14 days of life, results in improved growth as measured by weight or length at 28 weeks. The secondary specific aim is to a) determine the effect of nutritional supplementation on head circumference as an indicator of cerebral growth; immune status; opportunistic infection; and quality of life, and b) to evaluate the long term tolerability (28 weeks) of a concentrated formula compared to a standard formula in HIV-infected infants and the short term tolerability (8 weeks) of a concentrated formula compared to a standard formula in all HIV-exposed infants.