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ACTG 366: NOVEL ANTIRETROVIRAL THERAPY IN ANTIRETROVIRAL EXP CHILD

ACTG 366: NOVEL ANTIRETROVIRAL THERAPY IN ANTIRETROVIRAL EXP CHILD
ACTG 366：抗逆转录病毒治疗儿童的新型抗逆转录病毒疗法
批准号：
6264294
负责人：
ELIZABETH G MCFARLAND
金额：
$1.99万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6264294
关键词：
AIDS therapy HIV infections antiAIDS agent child (0-11) clinical research clinical trial phase I combination chemotherapy drug administration rate /duration drug screening /evaluation helper T lymphocyte human immunodeficiency virus 1 human subject human therapy evaluation nevirapine pediatric AIDS pharmacokinetics protease inhibitor ritonavir virus RNA virus load

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中文摘要
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英文摘要
This trial is designed to evaluate whether four drug combination therapies based on prior antiretroviral experience can maximally decrease viral load and increase CD4 cells. The primary objectives are 1) to determine the proportion of subjects in each Group having reduction in HIV-1 RNA when all antiretroviral agents are changed and at least 2 of the agents are novel and to determine the duration of the reduction; 2) To evaluate the safety and tolerance of these combinations based on clinical and laboratory toxicities; and 3) to determine the steady-state pharmacokinetics of nevirapine, nelfinavir and ritonavir when used in combination with respect to age and treatment group.
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  • 批准号：
    6114937
  • 项目类别：
  • 资助金额：
    $1.99万
  • 财政年份：
    1998
  • 负责人：
    ELIZABETH G MCFARLAND
  • 依托单位：
    UNIVERSITY OF COLORADO DENVER
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  • 批准号：
    6114989
  • 项目类别：
  • 资助金额：
    $1.99万
  • 财政年份：
    1998
  • 负责人：
    ELIZABETH G MCFARLAND
  • 依托单位：
    UNIVERSITY OF COLORADO DENVER
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  • 批准号：
    6264279
  • 项目类别：
  • 资助金额：
    $1.99万
  • 财政年份：
    1998
  • 负责人：
    ELIZABETH G MCFARLAND
  • 依托单位：
    UNIVERSITY OF COLORADO DENVER
ACTG#316--PHASE III NEVIRAPINE FOR PREVENTION OF MATERNAL-FETAL TRANS. OF HIV
  • 批准号：
    6114994
  • 项目类别：
  • 资助金额：
    $1.99万
  • 财政年份：
    1998
  • 负责人：
    ELIZABETH G MCFARLAND
  • 依托单位：
    UNIVERSITY OF COLORADO DENVER
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