NATURAL HISTORY, PREVENTION AND TREATMENT OF RECURRENT VIRAL HEPATITIS B & C

复发性乙型病毒性肝炎的自然史、预防和治疗

• 批准号: 6218483
• 负责人: Mitchell L Shiffman
• 金额: $ 0.06万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6218483
• 关键词: clinical research; clinical trials; combination therapy; drug screening /evaluation; hepatitis B; hepatitis C; hepatitis C virus; human subject; human therapy evaluation; immunoglobulins; immunotherapy; interferon alpha; lamivudine; liver disorder chemotherapy; liver transplantation; longitudinal human study; nucleoside analog; outcomes research; pathologic process; postoperative complications; relapse /recurrence

To determine the natural history and effectiveness of long term HBIG with or without coadministration of the nucleoside analog lamivudine in persons with hepatitis B following orthotopic liver transplantation.To determine the progression of recurrent Hepatitis C with or without interferon alpha in persons following orthotopic liver transplantation.

目的：确定联合或不联合应用核苷类似物拉米夫定的长期HBIG对原位肝移植后乙肝患者的自然病史和疗效，以及在有或无干扰素的情况下原位肝移植后丙型肝炎复发的进展情况。