上颌窦造口患者的治疗-猫眼课题宝

上颌窦造口患者的治疗

批准号：

6115028

负责人：

PHYLLIS GARDNER

金额：

$4.03万

依托单位：

STANFORD UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

1998

资助国家：

美国

项目状态：

已结题

起止时间：

1998-12-01 至 1999-11-30

来源：

https://reporter.nih.gov/project-details/6115028

关键词：

clinical research cystic fibrosis human subject human therapy evaluation lavage therapy oral pharyngeal surgery paranasal sinus respiratory epithelium respiratory surgery sinusitis

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英文摘要

Cystic fibrosis (CF) is a common genetic disorder characterized by defective epithelial chloride transport and progressive, lethal lung disease. Chronic sinusitis, which clinically plagues approximately 50% of CF patients, is treated at Stanford with a combination of maxillary antrotomy placement followed by monthly maxillary sinus tobramycin lavage. A total of five patients have been enrolled in protocol 438, an evaluation of maxillary sinus treatments in patients with antrostomies. This randomized, double-blind comparison of maxillary sinus tobramycin lavage versus placebo is designed to document the effectiveness of tobramycin lavage and determine the rate of sinusitis recurrence. Nasal mucosa transepithelial potential differences are similar to maxillary sinus transepithelial differences, except that maxillary sinus transepithelial potential differences, during baseline determinations, are more sensitive to the effects of local chronic infection.

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