REGULATION OF GRANULOCYTOPOIESIS IN NEONATES WITH EARLY ONSET BACTERIAL SEPSIS

早发性细菌性脓毒症新生儿粒细胞生成的调节

• 批准号: 6114815
• 负责人: KURT R SCHIBLER
• 金额: $ 2.81万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6114815
• 关键词: bacterial disease; blood /lymphatic pharmacology; blood disorder chemotherapy; blood toxicology; chemotaxis; clinical research; clinical trials; colony stimulating factor; disease /disorder onset; human subject; human therapy evaluation; leukopenia; leukopoiesis; neutrophil; newborn human (0-6 weeks); pediatric pharmacology; recombinant proteins; superoxides

Administration of recombinant G-CSF to neonates with early-onset bacterial sepsis and neutropenia will be studied to determine effects upon the duration of neutropenia, and improvement of neutrophil chemotaxis and superoxide production in relation to length of illness.

重组粒细胞集落刺激因子治疗早产儿 将研究细菌性败血症和中性粒细胞减少症，以确定 在中性粒细胞减少症持续时间和中性粒细胞减少症改善后， 趋化性和超氧化物的产生与疾病的持续时间有关。