DOUBLE BLIND STUDY OF GCSF ADMINISTRATION TO NEONATES WITH NEUTROPENIA

GCSF 对中性粒细胞减少症新生儿给药的双盲研究

• 批准号: 6245959
• 负责人: KURT R SCHIBLER
• 金额: $ 2.15万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-06 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6245959
• 关键词: blood disorder chemotherapy; blood toxicology; clinical research; colitis; colony stimulating factor; drug screening /evaluation; granulocytopenia; human subject; human therapy evaluation; immunotherapy; newborn human (0-6 weeks); pediatric pharmacology; placebos; pregnancy toxemia /hypertension

The study will determine if G-CSF administration to newborn infants with neutropenia associated with possible congenital or acquired sepsis, maternal pregnancy-induced hypertension, or necrotizing entercolitis results in rapid resolution of neutropenia, improved netrophil function, less frequent and less severe illness, and improved survival compared to placebo-treated control infants.

这项研究将确定G-CSF是否适用于患有 与可能的先天性或获得性败血症相关的中性粒细胞减少症， 母体妊娠高血压综合征或坏死性肠炎 结果中性粒细胞减少症迅速缓解，中性粒细胞功能改善， 相比，更少的频率和更轻的疾病，以及更高的存活率 到接受安慰剂治疗的对照组婴儿。