MISOPROSTOL EFFECTS ON BLOOD PRESSURE CHANGES IN ESSENTIAL HYPERTENSION

这项建议测试了米索前列醇减轻双氯芬酸钠(一种非类固醇消炎药)引起的老年盐敏感型I-II期高血压患者血压升高的假说。米索前列醇是一种前列腺素E2类似物，已被证明可以减弱单剂量口服布洛芬对肾小球滤过率、肾脏血流量和血压的影响。这项研究由首席调查员构思，由Searle制药公司提供的无限制赠款支持。该提案被认为是由首席调查员及其同事发起的、以假设为导向的研究，并不被认为是由制药公司赞助的临床试验。这项研究已经完成，并证实了这一假设。

This proposal tested the hypothesis that misoprostol attenuates the rise in blood pressure induced by diclofenac sodium (a non-steroidal anti-inflammatory drug) in elderly patients with salt-sensitive, stage I-II essential hypertension. Misoprostol is a prostaglandin E2 analog that had been shown to attenuate the effects of single-dose oral ibuprofen on glomerular filtration rate, renal blood flow, and on blood pressure. This study, conceived by the Principal Investigator, was supported by an unrestricted grant-in-aid from the Searle pharmaceutical company. The proposal was considered an investigator-initiated, hypothesis-oriented study generated by the Principal Investigator and his associates, and was not considered to be a drug company-sponsored clinical trial. This study has been completed, and the hypothesis confirmed.