PCR DIAGNOSIS OF ENTEROVIRAL INFECTIONS IN FEBRILE INFANTS

发热婴儿肠道病毒感染的PCR诊断

• 批准号: 6218445
• 负责人: Carrie L. Byington
• 金额: $ 0.16万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6218445
• 关键词: Enterovirus; bacterial disease; clinical research; diagnostic tests; human subject; hyperthermia; infant human (0-1 year); polymerase chain reaction

Dr. Byington is testing the hypothesis that polymerase chain reaction-based rapid diagnostic methods can define the presence or absence of bacterial infections in young infants who present to the emergency room with fevers. The data generated in this protocol, now completed, have indicated that the detection of non-polio enteroviral infections in febrile infants serves as a useful indication that bacterial infection is not likely to be present. Thus, lengthy hospitalizations with expensive antibiotic therapy and invasive diagnostic studies may not be required. The data generated by this study were used in a successful application to the Robert Wood Johnson Foundation to launch an expanded study.

Byington博士正在测试一种假设，即基于聚合酶链反应的快速诊断方法可以确定因发烧而进入急诊室的婴幼儿是否存在细菌感染。本方案中生成的数据（现已完成）表明，发热婴儿中非脊髓灰质炎肠道病毒感染的检测可作为细菌感染不太可能存在的有用指示。因此，可能不需要长时间的住院治疗和昂贵的抗生素治疗和侵入性诊断研究。 本研究生成的数据已成功应用于Robert Wood约翰逊基金会，以启动一项扩展研究。