REGIONAL PRIMATE RESEARCH CENTER SUPPORT

本申请是GRANT P51 RR00167的五年续期，并且 包括要求进行与艾滋病有关的研究，并要求改进和 现代化。我们在研究、服务和 设施。 威斯康星州区域灵长类研究中心(WRPRC)进行了一项 与人类健康相关的基础和战略研究，其中 非人灵长类在分子、细胞和生物水平的研究 探究对于促进人类和人类的知识是必不可少的 疾病。该中心位于威斯康星大学校园内- 麦迪逊，是全面融入和创业发展的 与校园内50多个部门进行跨学科研究，以及 区域、国家和国际方案，服务于近200个 调查人员。该中心鼓励合作研究新的 调查人员。 研究项目集中在六个领域，每个领域对NIH来说都是高度优先的。这些 以下是举例说明： I.衰老和代谢性疾病：饮食限制、 衰老、肥胖、糖尿病。 二、免疫学和病毒学：粘膜传播，发病机制， 诊断学，疫苗。 三、神经生物学：青春期神经内分泌学，神经元可塑性， 幻象。 四、生理行为学：调节生殖的最新机制 成功。 五、心理生物学：发育行为、产前应激、 神经毒理学。 六、生殖与发育：配子生物学、受精、茎 细胞生物学、着床、生育调节。 研究服务为研究团队提供最先进的支持 以提高研究质量和效率的成本和效率 竞争力。其中包括动物服务，并有专门的团队来 确保我们的动物护理和遗传管理的最高质量 繁育计划。化验服务、图书馆和信息服务、 病理学服务、生殖研究服务和分子生物学 核心。 业务服务，包括业务办公室、数据管理和 商店服务确保积极有效的管理、基础设施 支持和沟通。我们继续进行强有力的翻修计划。我们 将于1996年开始建造一座新大楼，以集中专家研究 衰老、艾滋病和发育生物学中的菌落，并提供新的 为我们的兽医和病理服务提供住宿和设施。

This application is for a five year renewal of Grant P51 RR00167 and includes requests for AIDS related research, and for improvement and modernization. We present new initiatives in research, services and facilities. The Wisconsin Regional Primate Research Center (WRPRC) carries out fundamental and strategic research, with relevance to human health, where non-human primate studies at molecular, cellular and organismal levels of inquiry are essential to advance knowledge of the human and of human disease. The Center, located on the campus of the University of Wisconsin- Madison, is fully integrated and entrepreneurial in the development of interdisciplinary research with over 50 departments across campus, and regional, national and international programs, serving nearly 200 investigators. The Center encourages collaborative research for new investigators. Research Programs focus in six areas, each of high priority for NIH. These are, with examples: i. Aging and Metabolic Disease: dietary restriction, biomarkers of aging, obesity, diabetes. ii. Immunology and Virology: mucosal transmission, pathogenesis, diagnostics, vaccines. iii. Neurobiology: neuroendocrinology of puberty, neuronal plasticity, vision. iv. Physiological Ethology: proximate mechanisms regulating reproductive success. v. Psychobiology: developmental behavior, prenatal stress, neurotoxicology. vi. Reproduction and Development: gamete biology, fertilization, stem cell biology, implantation, fertility regulation. Research Services provide state of the art support to the research teams at a cost and efficiency that enhances research quality and competitiveness. These include Animal Services, with dedicated teams to ensure the highest quality of animal care and genetic management of our breeding programs. Assay Services, Library and Information Services, Pathology Services, Reproduction Research Services and a Molecular Biology Core. Operational Services, including the Business Office, Data Management and Shop Services ensure active and effective management, infrastructural support and communication. We continue a strong renovation program. We will commence a new building in 1996 to centralize specialist research colonies in Aging, AIDS and Developmental Biology, and to provide new accommodation nd facilities for our veterinary and pathology services.