NORTH AMERICAN STUDY OF TREATMENT FOR REFRACTORY ASCITES (NASTRA)

北美顽固性腹水治疗研究 (NASTRA)

• 批准号: 6116984
• 负责人: KENT G BENNER
• 金额: $ 3.13万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116984
• 关键词: ascites; cardiovascular shunt surgery; clinical research; clinical trials; diuretics; health care cost /financing; human subject; human therapy evaluation; liver cirrhosis; liver transplantation; nutrition; portal hypertension; quality of life

This NIH-sponsored, multicenter randomized clinical trial is designed to compare the safety and efficacy of transjugular intrahepatic portosystemic shunt (TIPS) to total paracentesis for refractory ascites in cirrhotic patients. The effects of TIPS on the pathophysiology of portal hypertension will also be examined. Additional endpoints to be examined include cost of care, quality of life, diuretic doses, need for liver transplantation and nutritional status.

这项由NIH赞助的多中心随机临床试验设计为 比较跨循环肝内门植物的安全性和功效 cirrhotic中难治性腹水的全部可肠术的分流（尖端） 患者。 尖端对门户病理生理学的影响 还将检查高血压。 需要检查的其他端点 包括护理成本，生活质量，利尿剂剂量，需要肝脏 移植和营养状况。