PHASE I STUDY OF HIGH DOSE INTERMITTENT CALCITRIOL IN ADVANCED MALIGNANCIES

1，25-二羟基维生素D及其类似物的抗增殖作用 已经在组织培养和动物模型中证明了许多 不同的人类癌症。间歇性接触1，25-二羟基维生素D 在体外抑制肿瘤细胞的生长，可能足以实现 体内抗增殖作用。维生素D对人体的毒性， 主要是高钙血症，随着接触维生素的时间延长而增加 D. 他们研究的假设是，间歇给药可能会产生 1，25-二氢维生素D的抗增殖水平，同时最小化 毒性。这种间歇给药还没有被研究过，而且最大限度地 间歇给药的耐受量1，25-二羟基维生素D没有 已经被定义了。我们试图定义最大耐受量和最佳剂量 间歇给药的骨化三醇治疗方案。

Antiproliferative effects of 1,25-dihydroxyvitamin D and its analogues have been demonstrated in tissue culture and animal models of many different human cancers. Intermittent exposure to 1,25-dihydroxyvitamin D suppresses neoplastic cell growth in vitro and maybe sufficient to achieve antiproliferative effects in vivo. Toxicity of Vitamin D in humans, principally hypercalcemia, increases with duration of exposure to vitamin D. The hypothesis of they study is that intermittent dosing may produce antiproliferative levels of 1,25-disydroxyvitamin D while minimizing toxicity. Such intermittent dosing has not been studied and maximally tolerated doses of 1,25-dihydroxyvitamin D given intermittently have not been defined. We seek to define the maximally tolerated dose and optimal treatment schedule of Calcitriol delivered intermittently.