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ACTG254--MICRONIZED ATOVAQUONE & AT/AZ AS COMPARED TO TM/ SMX

ACTG254--MICRONIZED ATOVAQUONE & AT/AZ AS COMPARED TO TM/ SMX
ACTG254--微粉化阿托伐醌
批准号：
6264756
负责人：
RICHARD RUTSTEIN
金额：
$0.06万
依托单位：
CHILDREN'S HOSP OF PHILADELPHIA
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6264756
关键词：
AIDS therapy HIV infections antibacterial agents atovaquone azithromycin chemoprevention clinical research clinical trial phase I combination chemotherapy drug interactions human data human subject human therapy evaluation infant human (0-1 year) pediatric AIDS pharmacokinetics preschool child (1-5) sulfamethoxazole trimethoprim

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中文摘要
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英文摘要
ACTG 254 is a comparative study of two drug combinations (atovaquone/azithromycin vs. trimethoprim/sulfamethoxazole) for the prevention of serious bacterial infections in HIV-infected children. The lower age limit for enrollment into this study was lowered to 3 months (from 2 years) in March 1997. On February 12, 1999, this study will close to accrual of patients older than 19 months of age. Treatment and data collection continue in all age cohorts. Preliminary data from a pharmacokinetic substudy suggest that there is no pharmacokinetic interaction between atovaquone and azithromycin. No preliminary efficacy data are available from this study.
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