ACTG300--ZDV/3TC VS DDI MONOTHERAPY VS ZDV + DDI IN HIV INFECTED CHILDREN

ACTG300--ZDV/3TC 与 DDI 单药疗法与 ZDV DDI 在 HIV 感染儿童中的比较

• 批准号: 6116883
• 负责人: RICHARD RUTSTEIN
• 金额: $ 2.47万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116883
• 关键词: 2'3' dideoxyinosine; AIDS therapy; HIV infections; antiAIDS agent; clinical research; combination chemotherapy; human subject; human therapy evaluation; lamivudine; pediatric AIDS; zidovudine

Six patients have been enrolled at CHOP into this randomized, double- blind, comparative antiretroviral study. Originally, this study compared treatment with Zidovudine (ZDV) plus Lamivudine (3TC) versus ZDV plus ddI versus ddI monotherapy in HIV-infected children. Based on data from another ACTG study (ACTG 152), randomization to combination therapy with ZDV plus ddI ceased in June, 1996. This study had closed to enrollment of patients and all patients have completed study treatment.

6名患者在CHOP入组了这项随机、双盲、 盲法抗逆转录病毒比较研究最初，这项研究比较了 齐多夫定（ZDV）联合拉米夫定（3TC）治疗与ZDV联合ddI治疗 与ddI单药治疗相比。数据基于 另一项ACTG研究（ACTG 152），随机接受联合治疗， ZDV + ddI于1996年6月停止。本研究已关闭入组， 所有患者均已完成研究治疗。