课题基金 / 基金详情

EFFECTS OF DIETARY AND LOVASTATIN TREATMENTS IN PATIENT WITH CEREBROTENDIOS

EFFECTS OF DIETARY AND LOVASTATIN TREATMENTS IN PATIENT WITH CEREBROTENDIOS
饮食和洛伐他汀治疗对 Cerebrotendio 患者的影响
批准号：
6116943
负责人：
WILLIAM E CONNOR
金额：
$3.13万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6116943
关键词：
cerebrotendinous xanthomatosis cholestane compound clinical research clinical trials diet therapy human subject human therapy evaluation lovastatin metabolism disorder chemotherapy nutrition related tag steroid biosynthesis steroid metabolism

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中文摘要
翻译
患有这种遗传性疾病，肌腱黄瘤病， 不寻常的是，他们的血浆胆固醇水平是正常的，但他们 有很大的肌腱瘤 他们的血浆和组织 胆汁中胆甾烷醇水平和鹅去氧胆酸含量降低。 的 建议的研究涉及喂养不含胆固醇和胆甾烷醇的 饮食和使用药物，洛伐他汀和鹅去氧胆酸， 降低血液中的胆固醇水平。 胆固醇和胆甾烷醇 合成和周转的个别固醇。
英文摘要
Patients with this genetic disease, cerebrotendinous xanthomatosis, are unusual in that their plasma cholesterol levels are normal and yet they have large tendon xamthomas. They have elevated plasma and tissue cholestanol levels and reduced chenodeoxycholic acid content of bile. The proposed studies involve the feeding of a cholesterol and cholestanol-free diet and the use of medications, lovastatin and chenodeoxycholic acid, to reduce cholestanol levels in the blood. Cholesterol and cholestanol synthesis and the turnover of individual sterols..
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CAROTENOIDS AND LIPIDS IN AGE-RELATED MACULAR DEGENERATION
Effects of diet and medication in patients with CTX
Carotenoids and Lipids in Age-Related Macular Degeneration
STEROL METABOLISM & DIETARY CHOLESTEROL IN SLO SYNDROME