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EFFECTS OF DIETARY AND LOVASTATIN TREATMENTS IN PATIENT WITH CEREBROTENDIOS

EFFECTS OF DIETARY AND LOVASTATIN TREATMENTS IN PATIENT WITH CEREBROTENDIOS
饮食和洛伐他汀治疗对 Cerebrotendio 患者的影响
批准号：
6116943
负责人：
WILLIAM E CONNOR
金额：
$3.13万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6116943
关键词：
cerebrotendinous xanthomatosis cholestane compound clinical research clinical trials diet therapy human subject human therapy evaluation lovastatin metabolism disorder chemotherapy nutrition related tag steroid biosynthesis steroid metabolism

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英文摘要
Patients with this genetic disease, cerebrotendinous xanthomatosis, are unusual in that their plasma cholesterol levels are normal and yet they have large tendon xamthomas. They have elevated plasma and tissue cholestanol levels and reduced chenodeoxycholic acid content of bile. The proposed studies involve the feeding of a cholesterol and cholestanol-free diet and the use of medications, lovastatin and chenodeoxycholic acid, to reduce cholestanol levels in the blood. Cholesterol and cholestanol synthesis and the turnover of individual sterols..
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