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EFFECTS OF NONSTEROIDAL ANTIINFLAMMATORY AGENTS ON THYROID HORMONE LEVELS

EFFECTS OF NONSTEROIDAL ANTIINFLAMMATORY AGENTS ON THYROID HORMONE LEVELS
非甾体抗炎药对甲状腺激素水平的影响
批准号：
6116956
负责人：
MARY H SAMUELS
金额：
$3.13万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6116956
关键词：
clinical research drug administration rate /duration drug screening /evaluation human subject molecular site nonsteroidal antiinflammatory agent thyroid hormone binding protein thyroid hormones

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英文摘要
This protocol investigates effects of nonsteroidal antiinflammatory agents (NSAIDs) on serum thyroid hormone levels in healthy subjects. Subjects will receive on of six NSAIDs at therapeutic doses for one week, with frequent measurement of thyroid hormone levels. Our hypothesis is that NSAIDs displace thyroid hormones from serum protein binding sites, leading to increased free hormone levels and suppression of TSH levels.
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