SCREENING FOR ABNORMALITIES IN CDK4 GENE IN PATIENTS W/ TYPE 1 & TYPE

筛查 1 型患者的 CDK4 基因异常

• 批准号: 6264831
• 负责人: Guenther Boden
• 金额: $ 5.92万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6264831
• 关键词: cell cycle; clinical research; diabetes mellitus genetics; genetic screening; human subject; insulin dependent diabetes mellitus; noninsulin dependent diabetes mellitus

The objective of the current study is to screen patients with Type 1 or Type 2 diabetes mellitus for abnormalities of the CDK4 gene (a cell cycle gene). It is well established that genetic predisposition plays a major role in the pathogenesis of both Type 1 and Type 2 diabetes. Extensive studies by many laboratories over the past 15 years have identified several gene mutations which together, however, can account for less than 5% of diabetes. Hence the genetic defects in over 95% of the diabetic patients remain unknown.

当前研究的目的是筛查1型或2型糖尿病患者的CDK4基因（一种细胞周期基因）异常。众所周知，遗传易感性在1型和2型糖尿病的发病机制中起着重要作用。在过去的15年里，许多实验室进行了广泛的研究，已经确定了几种基因突变，然而，这些突变加在一起只能占不到5%的糖尿病。因此，超过95%的糖尿病患者的遗传缺陷仍然是未知的。