VARIABILITY OF THE HUMAN MELATONIN PHASE RESPONSE CURVE

人类褪黑素相位反应曲线的可变性

• 批准号: 6116926
• 负责人: ALFRED J LEWY
• 金额: $ 3.13万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116926
• 关键词: adult human (21+); circadian rhythms; clinical research; clinical trials; hormone therapy; human subject; human therapy evaluation; melatonin; oral administration; sleep disorders

This is a double-blind, placebo controlled clinical trial of oral melatonin administration in sighted subjects between the ages of 21 and 65. The specific goal of this project is to characterize the shape of the melatonin phase response curve (PRC) in subjects age 21 to 65. Other study objectives are: 1) to characterize the shape of the melatonin PRC, 2) to assess the variability of the shape of the PRC, and 3) to develop melatonin as a treatment for circadian phase disorders.

这是一项双盲、安慰剂对照的口服 褪黑激素给药于21岁和22岁之间的视力受试者 65. 该项目的具体目标是描述 年龄在21至65岁的受试者中的褪黑激素相位响应曲线（PRC）。 其他 研究目的是：1）表征褪黑激素PRC的形状， 2)评估中华人民共和国形状的可变性，以及3）开发 褪黑激素作为昼夜节律紊乱的治疗。