SUBTHALAMIC VERSUS PALLIDAL STIMULATION IN PARKINSONS DISEASE

帕金森病的丘脑底脑刺激与苍白球刺激

• 批准号: 6116989
• 负责人: KIM J BURCHIEL
• 金额: $ 3.13万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116989
• 关键词: Parkinson's disease; abnormal involuntary movement; clinical research; human subject; human therapy evaluation; lenticular nucleus; neurosurgery; subthalamus

Deep brain stimulation in both the globus pallidum (GPi) and subthalamic nucleus (STN) has been reported to be effective in control of Parkinsonian symptoms. However, the relative safety and efficacy of long-term GPi versus STN stimulation has not been investigated. The goal of the present study is to determine in a prospective, randomized manner the safety of subthalamic and pallidal stimulation in the control of Parkinsonian dyskinesias, akinesia and rigidity and to examine the efficacy of stimulation at either target in the function outcome of patients with Parkinson's Disease.

苍白球(GPI)和丘脑底核的脑深部刺激 据报道，核团(STN)对控制帕金森氏症有效 症状。然而，长期GPI的相对安全性和有效性 对STN的刺激还没有被研究。当前的目标是 研究的目的是以前瞻性、随机化的方式确定 丘脑底核和苍白球刺激对帕金森病的控制作用 运动障碍、运动障碍和僵直，并检查其疗效 对任一靶点的刺激对高血压患者功能结局的影响 帕金森氏症。