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A PHASE II/III STUDY OF SNX-111 FOR NONMALIGNANT PAIN

A PHASE II/III STUDY OF SNX-111 FOR NONMALIGNANT PAIN
SNX-111 治疗非恶性疼痛的 II/III 期研究
批准号：
6116965
负责人：
KIM J BURCHIEL
金额：
$3.13万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6116965
关键词：
analgesia calcium channel blockers calcium flux clinical research dorsal horn drug delivery systems drug screening /evaluation human subject neurons pain

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英文摘要
SNX-111 (IND#45718) is a voltage-sensitive calcium channel blocker that specifically blocks neuronal (N-type) calcium channels. These channels are found in highest density within the substantia gelatinosa of the dorsal horn, where blockade of calcium influx has been shown to create analgesia. The present study is designed to assess the safety and feasibility of intrathecal SNX-111 in relieving chronic, nonmalignant pain. Drug will be delivered via temp.intrathecal catheter/external pump or, in patients with previous device.
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