GROWTH HORMONE REPLACEMENT THERAPY IN CHILDHOOD ONSET HORMONE DEFICIENCY

生长激素替代疗法治疗儿童期激素缺乏症

• 批准号: 6264760
• 负责人: THOMAS MOSHANG
• 金额: $ 0.06万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6264760
• 关键词: bone density; clinical research; disease /disorder onset; endocrine disorder; hormone therapy; human subject; human therapy evaluation; longitudinal human study; photon absorptiometry; somatotropin

A total of 5 patients were recruited for screening to enter the study. The CRC tested all 5 patients. Two were found to be growth hormone sufficient and were not entered into the study. Of the remaining three patients, one was found to have a brain tumor recurrence just as he entered into the study and therefore was not continued in the study. The remaining 2 subjects continue in the study without untoward effects. Both had DEXA scans (core lab of CRC) and will be followed for the next 2 years with DEXA scans evaluating bone mineral density yearly. Four patients are scheduled to be tested in the next 6 months.

共招募5例患者进行筛选以进入研究。 CRC对所有5名患者进行了检测。 发现2例生长激素充足，未进入研究。 在其余3例患者中，1例患者在进入研究时发现脑肿瘤复发，因此未继续参与研究。 其余2例受试者继续参与研究，未出现不良反应。 两人都进行了DEXA扫描（CRC核心实验室），并将在接下来的2年内每年进行DEXA扫描评估骨密度。 计划在未来6个月内对4名患者进行检测。