TOPICAL HEXA-FLUORO 1,25-DIHYDROVITAMIN D3 IN TREATING PSORIASIS

外用六氟 1,25-二氢维生素 D3 治疗牛皮癣

• 批准号: 6117220
• 负责人: MICHAEL F HOLICK
• 金额: $ 3.05万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6117220
• 关键词: 1,25 dihydroxycholecalciferol; clinical research; combination therapy; fluorine; human subject; human therapy evaluation; outcomes research; petroleum oil; psoriasis; skin disorder chemotherapy; topical drug application; vitamin analog; vitamin therapy

The purpose of this study is to determine the usefulness of F6-1,25(OH)2D3 in controlling psoriasis. Two lesions will be chosen for the study, one will have F6-1,25(OH)2D3 in Vaseline, the other will receive plain Vaseline. At the end of two months, three biopsies will be taken, one biopsy of lesion treated with F6-1,25(OH)2D3, one biopsy of lesion treated with Vaseline alone, and another biopsy of uninvolved normal skin.

本研究的目的是确定F6- 1，25（OH）2D 3在控制银屑病中的有用性。 本研究将选择两处病变，一处将使用凡士林中的F6- 1，25（OH）2D 3，另一处将使用普通凡士林。 在两个月结束时，将进行三次活检，一次是用F6- 1，25（OH）2D 3治疗的病变的活检，一次是仅用凡士林治疗的病变的活检，另一次是未受累的正常皮肤的活检。