ROLE OF SELF HYPNOSIS IN HEPATITIS B VACCINATIONS W/ RESPECT TO DISTRESS

自我催眠在乙型肝炎疫苗接种中的作用

• 批准号: 6264990
• 负责人: ROBERT M JACOBSON
• 金额: $ 2.01万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6264990
• 关键词: active immunization; antibody formation; child (0-11); child psychology; clinical research; clinical trial phase I; hepatitis B; hepatitis B antigens; hepatitis B virus group; hepatitis vaccine; human subject; hypnosis; psychoneuroimmunology

The purposes of this investigation are to: a) determine if self hypnosis with a specific suggestion to prevent distress results in a reduction in distress in a large cohort of children undergoing hepatitis B vaccination; and b) determine if self hypnosis with a specific suggestion to increase immune response results in an increase in antibody to hepatitis B surface antigen (Anti-HBs) levels following immunization in a large cohort of children undergoing hepatitis B vaccination. We have enrolled 125 subjects. Ninety subjects have completed the entire intervention and have received renumeration. We intend to enroll 192 subjects. Thirty-two more have been scheduled, and we have yet to identify the remaining 35 subjects. Recruitment efforts continue through IRB-approved methods including brochures distributed to enrolled subjects and other means.

本研究的目的是：a)在一大批接受乙型肝炎疫苗接种的儿童中，确定自我催眠与预防焦虑的特定建议是否能减少焦虑；b)确定在一大批接受乙型肝炎疫苗接种的儿童免疫接种后，在特定建议下进行自我催眠以增加免疫应答是否会导致乙型肝炎表面抗原抗体（Anti-HBs）水平的增加。我们招募了125名受试者。90名受试者完成了整个干预并获得了报酬。我们打算招募192名受试者。另有32人已被安排，我们尚未确定其余35人的身份。招聘工作继续通过审查委员会批准的方法进行，包括向登记受试者分发小册子和其他方式。