NICOTINE PATCH TREATMENT AS AN ANORECTIC

尼古丁贴片治疗厌食症

• 批准号: 6264957
• 负责人: DENISE M DUPRAS
• 金额: $ 2.01万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6264957
• 关键词: anorexic agent; bioenergetics; clinical research; clinical trial phase I; human subject; nicotine replacement; nutrient intake activity; nutrition related tag

This is a randomized, double-blind placebo controlled study of the effects of transdermal nicotine on human metabolism. The outcomes being assessed include the effects of transdermal nicotine on resting energy expenditure measure by indirect calorimetry, body composition measured by DEXA scan, reported caloric intake and activity. To date, 198 individuals called expressing an interest in the study. Of those, 64 passed phone screen and 31 were eligible after additional testing and physical examination. Eighteen have completed the study. Three subjects dropped from the study due to adverse effects including nausea, vomiting, and dizziness. We anticipate completion of the study by 9/30/99. Data analysis is pending completion of the study. We are currently assessing the feasibility of direct electronic transfer of data to facilitate analysis.

这是一项随机、双盲、安慰剂对照研究，研究尼古丁透皮给药对人体代谢的影响。 评估的结果包括经皮尼古丁对间接测热法测量的静息能量消耗、DEXA扫描测量的身体组成、报告的热量摄入和活动的影响。到目前为止，有198人表示对这项研究感兴趣。 其中，64人通过了手机筛查，31人在经过额外测试和体检后符合资格。 18人完成了研究。 3名受试者因不良反应（包括恶心、呕吐和头晕）退出研究。 我们预计这项研究将于1999年9月30日完成。数据分析有待研究完成。 我们现正评估直接以电子方式传送数据的可行性，以方便分析。