NICOTINE PATCH TREATMENT AS AN ANORECTIC

这是一项关于尼古丁对人体新陈代谢影响的随机、双盲、安慰剂对照研究。正在评估的结果包括透皮尼古丁对间接量热法测量的静息能量消耗的影响，通过DEXA扫描测量的身体成分，报告的卡路里摄入量和活动量。到目前为止，已有198人打电话表示对这项研究感兴趣。其中，通过了电话筛查，31人通过了额外的测试和体检。已有18人完成了这项研究。三名受试者因恶心、呕吐和头晕等不良反应而退出研究。我们预计这项研究将于1999年9月30日前完成。数据分析正在等待这项研究的完成。我们现正评估直接以电子方式传送数据的可行性，以方便分析。

This is a randomized, double-blind placebo controlled study of the effects of transdermal nicotine on human metabolism. The outcomes being assessed include the effects of transdermal nicotine on resting energy expenditure measure by indirect calorimetry, body composition measured by DEXA scan, reported caloric intake and activity. To date, 198 individuals called expressing an interest in the study. Of those, 64 passed phone screen and 31 were eligible after additional testing and physical examination. Eighteen have completed the study. Three subjects dropped from the study due to adverse effects including nausea, vomiting, and dizziness. We anticipate completion of the study by 9/30/99. Data analysis is pending completion of the study. We are currently assessing the feasibility of direct electronic transfer of data to facilitate analysis.