CORRECTION OF PANCREATIC STEATORRHEA DETECTED BY NOVEL METHOD

新方法检测到的胰腺脂肪泻的校正

• 批准号: 6264975
• 负责人: E DIMAGNO
• 金额: $ 2.01万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6264975
• 关键词: clinical research; clinical trial phase I; dietary lipid; human subject; human therapy evaluation; lipase; metabolism disorder chemotherapy; metabolism disorder diagnosis; pancreatitis; steatorrhea

This protocol has two main objectives: 1) to study a novel test for steatorrhea and 2) to study the effect of fat content of meal on steatorrhea of chronic pancreatitis treated with porcine pancreatic lipase. This protocol consists of two linked, but slightly different protocols. In the parent protocol (37-98-00), we studied three patients. Because of the gastric intubation part of the protocol and the requirement for relatively long stays in the GCRC, we elected to amend the protocol (37-98-01). The protocol now only involves collection of two 72-hour stools while patients are on a special diet at home. There is no GCRC stay involved. Recruitment of patients is slightly increased in protocol #37-98-01. We intend to enter suitable patients into the parent protocol (37-98-00) or the amended (37-98-01) protocol pending patient acceptance. The trend for most patients is to do the study at home, rather than spending time in the Saint Marys GCRC. To date, there are no publications resulting from the work done in the protocol.

该方案有两个主要目的：1)研究一种新的脂肪泻检测方法；2)研究餐中脂肪含量对猪胰腺脂肪酶治疗慢性胰腺炎脂肪泻的影响。该协议由两个链接但略有不同的协议组成。在父母方案(37-98-00)中，我们研究了三名患者。由于协议中的胃插管部分和在GCRC停留时间相对较长的要求，我们选择修改协议(37-98-01)。该方案现在只涉及在患者在家进行特殊饮食时收集两张72小时大便。没有GCRC继续参与其中。在37-98-01号方案中，患者招募人数略有增加。我们打算将合适的患者纳入父协议(37-98-00)或修订的(37-98-01)协议，等待患者接受。对于大多数患者来说，趋势是在家里进行研究，而不是花时间在圣玛丽GCRC。到目前为止，议定书中所做的工作尚未产生任何出版物。