SHORT-TERM (1 WEEK) INGESTION OF WHEAT AMYLATE INHIBITOR IN OBESITY AND DIABETES

本方案的目的是确定在糖尿病患者中给予小麦淀粉酶抑制剂1周对血糖和胃肠激素的影响。 六名糖尿病患者被喂食标准体重维持饮食3周。 在第一周，通常继续糖尿病治疗。在第三周停止使用小麦淀粉酶抑制剂和糖尿病药物。 在第7、14和21天，在餐前和餐后4小时内每1/2小时采血一次，用于血糖、C肽和HPP。在第二周（与第三周相比），δ血糖（曲线下面积）和C肽和HPP的浓度在晚餐后较低。 1例患者在使用小麦淀粉酶抑制剂后出现稀便，第6天改善。 小麦淀粉酶抑制剂可降低糖尿病患者的血糖，尤其是多餐时。 小麦淀粉酶抑制剂是治疗糖尿病的潜在有效和安全的药物，但需要在更多的糖尿病患者中进行长期研究以证实小麦淀粉酶抑制剂的有效性和安全性。

The aim of this protocol was to determine in diabetics the effect of giving wheat amylase inhibitor for 1 week on blood glucose and gastrointestinal hormones. Six diabetics were fed a standard weight maintenance diet for 3 weeks. During week I, usually therapy for diabetes mellitus was continued. Wheat amylase inhibitors and diabetic medications were withheld during the third week. On days 7, 14, and 21, blood was drawn before and every 1/2 hour for 4 hours postprandially for blood glucose, c-peptide and HPP. During week II (compared to week III), the delta blood glucose (area under the curve) and concentrations of c-peptide and HPP were lower in response to dinner. One patient developed loose stools on wheat amylase inhibitors that improved by day 6. Wheat amylase inhibitor lowers blood glucose in diabetes mellitus, more so with larger meals. Wheat amylase inhibitor is potentially useful and safe therapy for diabetes mellitus; however, long-term studies in more diabetics are needed to confirm the efficacy and safety of the wheat amylase inhibitor.