BARRETTS ESOPHAGUS--FAMILIAL DISORDER

巴雷茨食管——家族性疾病

• 批准号: 6264977
• 负责人: ALAN CAMERON
• 金额: $ 2.01万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6264977
• 关键词: clinical research; esophagus disorder; family genetics; genetic susceptibility; human subject

Aim of study: Barrett's esophagus is a disorder associated with reflux and an increased risk of esophageal cancer. We previously showed (Gastroenterology 1997; 113:1449-1456) an increased prevalence of symptoms of gastroesophageal reflux in first degree relatives of patients with Barrett's esophagus. The aim of the present study is to find whether first degree relatives of patients with Barrett's esophagus have an increased prevalence of this disorder compared to controls with reflux symptoms and no family history of Barrett's esophagus. Completed studies: So far, 117 probands with Barrett's esophagus have been invited to participate, 229 relatives were mailed information, and 100 relatives have returned our questionnaire. 35 of these had reflux symptoms, and 20 of these have completed the study with endoscopic examination (GCRC). Another 15 are due to come for study in the next few weeks. More probands and relatives are being recruited from the large Mayo data base and active practice of the investigators. A total of 29 matched controls have completed study concurrently (controls are studied by the investigators in a different endoscopic unit).

研究目的：巴雷特食管是一种与反流和食管癌风险增加相关的疾病。 我们以前的研究表明（Gastroenterology 1997; 113：1449-1456）Barrett食管患者的一级亲属中胃食管反流症状的患病率增加。 本研究的目的是找出与有反流症状且没有巴雷特食管家族史的对照组相比，巴雷特食管患者的一级亲属是否有这种疾病的患病率增加。已完成的研究：到目前为止，117例Barrett食管先证者已被邀请参加，229名亲属被邮寄信息，100名亲属已返回我们的问卷。 其中35人有反流症状，其中20人完成了内镜检查（GCRC）的研究。 另外15人将在未来几周内前来学习。 更多的先证者和亲属正在从马约的大型数据库和研究者的积极实践中招募。 共有29名匹配的对照组同时完成了研究（对照组由研究者在不同的内窥镜单位进行研究）。