FEASIBILITY OF IMAGING HYPERPOLARIZED 129XE

利用光学泵浦机制， 自旋超极化惰性气体可以被储存和积累， 未来的应用。 事实证明，这些强烈 极化气体可用于医学成像。 我们正在探索 利用吸收的、自旋超极化的129 π（π α）粒子的可行性 作为麻醉剂）用于医学成像。 第一，T1的129英寸 将测量生物液体;由于短T1是明显的 使用自旋超极化信号源的限制因素。 第二、 我们将验证我们是否能够生产出足够数量的 自旋超极化129 π。 第三，建立一个将资金转移到 想象的主体将被开发。 最终，我们会想象 在NMRFAM的小口径成像系统中， 23 Na成像探头。 由于增加的磁化强度， 超极化时，信噪比（S/N）应打开 目前在医学中进行的1H成像的S/N的顺序 应用. 吸入的毒气会扩散到全身， 为1H成像提供了有趣的补充。 核磁共振性质 （化学位移和关系时间）在很大范围内变化， 不同的生物环境，从而允许有趣的图像 对比度 自旋超极化~（129）Tc成像的可能应用 包括：肺空间成像;肺组织成像;脑血 流量测量;蛋白质示踪研究;和探测麻醉剂 行动上

With optical pumping mechanisms, large amounts of nuclear spin-hyperpolarized noble gases can be stored and accumulated for future applications. It has been demonstrated that these strongly polarized gases may be useful in medical imaging. We are exploring the feasibility of using absorbed, spin-hyperpolarized, 129Xe (Xe acts as an anesthetic) in medical imaging. First, T1's of 129Xe in biological fluids will be measured; as a short T1 is an obvious limiting factor in using spin-hyperpolarized signal sources. Second, we will verify that we can produce adequate amount of spin-hyperpolarized 129Xe. Third, a mechanism for Xe transfer to the imagining subject will be developed. Eventually, we will image Xe inhaled by a mouse in the NMRFAM's small-bore imaging system using the 23Na imaging probe. Because of the increased magnetization gained by the hyperpolarization, the signal-to-noise ratio (S/N) should be on the order of the S/N of 1H imaging currently performed in medical applications. Inhaled Xe gas will diffuse throughout the body and provide an interesting compliment to 1H imaging. Xe's NMR properties (chemical shift, and relation times) vary over a large range in different biological environments thus allowing for interesting image contrast. Possible applications for spin-hyperpolarized 129Xe imaging include: lung airspace imaging; lung tissue imaging; cerebral blood flow measurements; protein tracer studies; and probing anesthetic action.