MEASURE SELF DIFFUSION COEFFICIENT OF ALL SPECIES PRESENT IN REVERSE MICELLE SYS

测量反胶束系统中存在的所有物种的自扩散系数

• 批准号: 6298161
• 负责人: RONALD R BURNETTE
• 金额: $ 0.75万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-01 至 2000-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6298161
• 关键词: bioengineering /biomedical engineering; biological products; biomaterials; biomedical resource; biotechnology; drug /agent; nuclear magnetic resonance spectroscopy

Reverse micelles have a wide variety of applications. They can be used as microreactors to carry reactions of interest to the biotech industry and have numerous pharmaceutical applications relating to facilitating the delivery of drugs. However, for the full potential of these applications to be reached one must understand the environment that the solute experiences when placed inside a reverse micelle. In order to characterize this internal micelle environment, we are using 31P NMR to monitor the apparent pH of the water present inside the reverse micelles as a function of the water/surfactant ratios and oil/surfactant ratios. This information, when coupled with viscosity studies, allow us to delineate how the internal micelle environment is modified. We now propose to further characterize the reverse micelle, and its internal environment, by measuring the self-diffusion coefficients of all species present in the system through the use of Fourier Transform Pulsed Field Gradient Spin-Echo experiments.

反胶束具有广泛的应用。 它们可以 用作微反应器，以进行生物技术感兴趣的反应， 并具有许多与以下有关的药物应用： 以便于药物的输送。 然而，为了充分发挥潜力， 要达到这些应用程序，必须了解 环境，溶质的经验时，放置在一个反向 胶束 为了表征这种内部胶束环境， 我们使用31 P NMR来监测存在的水的表观pH 在反胶束内部作为水/表面活性剂的函数 比例和油/表面活性剂比例。 这些信息，如果与 粘度研究，使我们能够描绘内部胶束 环境被改造了。 我们现在建议进一步描述 反胶束及其内部环境，通过测量 系统中所有物质的自扩散系数 通过使用傅里叶变换脉冲场梯度自旋回波 实验