MEASURE SELF DIFFUSION COEFFICIENT OF ALL SPECIES PRESENT IN REVERSE MICELLE SYS

测量反胶束系统中存在的所有物种的自扩散系数

• 批准号: 6281528
• 负责人: RONALD R BURNETTE
• 金额: $ 0.27万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-01 至 1999-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6281528
• 关键词: bioengineering /biomedical engineering; biological products; biomaterials; biomedical resource; biotechnology; drug /agent; nuclear magnetic resonance spectroscopy

Reverse micelles have a wide variety of applications. They can be used as microreactors to carry reactions of interest to the biotech industry and have numerous pharmaceutical applications relating to facilitating the delivery of drugs. However, for the full potential of these applications to be reached one must understand the environment that the solute experiences when placed inside a reverse micelle. In order to characterize this internal micelle environment, we are using 31P NMR to monitor the apparent pH of the water present inside the reverse micelles as a function of the water/surfactant ratios and oil/surfactant ratios. This information, when coupled with viscosity studies, allow us to delineate how the internal micelle environment is modified. We now propose to further characterize the reverse micelle, and its internal environment, by measuring the self-diffusion coefficients of all species present in the system through the use of Fourier Transform Pulsed Field Gradient Spin-Echo experiments.

反胶束有各种各样的应用。它们可以是