PULMONARY ASPERGILLOMA

主要目的：比较伊曲康唑环糊精口服液与安慰剂(羟丙基-B-环糊精)治疗肺曲菌球的安全性和有效性。具体目的：1.评价伊曲康唑环糊精口服液治疗肺曲菌球的疗效和安全性。2.探讨伊曲康唑血药浓度与预后的关系。3.确定使用伊曲康扎洛环糊精口服液治疗的曲菌球患者亚群的发病率和死亡率。

Main Objective- to compare the safety and efficacy of itraconazole oral solution in cyclodextrin with placebo (hydroxypropyl-B-cyclodextrin) in the treatment of pulmonary aspergilloma. Specific Objectives: 1. To evaluate the efficacy and safety of itraconazole oral solution in cyclodextrin in the treatment of patients with pulmonary aspergilloma. 2. To determine association between serum itraconazole drug levels and outcome. 3. To identify subpopulations of patients with aspergilloma that would benefit in terms of morbidity and mortality by treatment with itraconzaloe oral solution in cyclodextrin.