CORRELATION BETWEEN QUANTITY OF ALVEOLAR EPITHELIAL CELL SPECIFIC ANTIGENS

肺泡上皮细胞特异性抗原数量之间的相关性

• 批准号: 6119893
• 负责人: VALERIE NEWMAN
• 金额: $ 2.58万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6119893
• 关键词: biomarker; clinical research; human subject; longitudinal human study; lung injury; newborn human (0-6 weeks); respiratory disorder diagnosis; respiratory epithelium; surface antigens

A prospective observational study of neonates at UCSF requiring tracheal intubation within 24 hours of birth to quantify the amount of alveolar type I epithelial cell specific antigens in tracheal secretions, and to characterize the changes in these antigen levels over time. These levels and the pattern of change intervals will be correlated to the extent of lung injury assessed clinically and to long term outcome variables such as chronic lung disease. The hypothesis is that the process of lung injury will be marked by increased shedding of type I cells.

UCSF中需要气管插管的新生儿的前瞻性观察研究 在出生后24小时内插管，以量化肺泡 气管分泌物中的I型上皮细胞特异性抗原，以及 表征这些抗原水平随时间的变化。这些水平 并且变化间隔的模式将与 临床评估的肺损伤和长期结果变量， 慢性肺病 假设肺损伤的过程 将以I型细胞脱落增加为标志。