RECRUITMENT OF PERIPHERAL BLOOD HEMOPOIETIC PROGENITORS BY GCSF

该方案是一项名为“免疫治疗靶向”的提案的一部分 人乳腺癌细胞体内免疫增强和培养 自体树突状细胞“。长期目标是利用 对于乳腺癌的免疫治疗，建议使用一种 发展人类乳腺癌动物模型的方法学。这 免疫治疗将侧重于利用自体细胞的独特能力 树突状细胞，强大的抗原提呈细胞，增强宿主 针对乳腺癌的免疫监控。这一阶段的研究 涉及从人外周CD34干细胞生成树突状细胞 并通过分离的方式收获它们。

This protocol is part of a proposal entitled "Immunotherapy targeting human breast cancer cells in vivo with immune-enhanced and educated autologous dendritic cells". With the long-term goal of utilizing immunotherapy for the treatment of breast cancer, it is proposed to use an animal model of human breast cancer to develop the methodology. This immunotherapy will focus on utilizing the unique capacity of autologous dendritic cells, potent antigen-presenting cells to enhance host immunosurveillance against breast cancer. This phase of the study involves generating dendritic cells from human peripheral CD34+ stem cells and harvesting them by means of apheresis.