ORAL GLUCOSE TOLERANCE TEST & PREPARATORY DIET

口服葡萄糖耐量测试

• 批准号: 6265656
• 负责人: JOAN M MASTROBATTISTA
• 金额: $ 1.11万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6265656
• 关键词: clinical research; diagnosis design /evaluation; dietary carbohydrates; gestational age; gestational diabetes mellitus; glucose tolerance test; human pregnant subject; metabolism disorder diagnosis; nutrition related tag

The administration of a preparatory diet containing 150 grams of carbohydrates/day for three days has been used for decades as a standard preparation for an oral glucose tolerance test (OGTT) for the diagnosis of gestational diabetes. The need for a preparatory diet in pregnant women needs to be confirmed. Avoiding the diet will result in simpler administration of the glucose tolerance test. The objective of this study is to determine whether a preparatory diet significantly alters the results of a glucose tolerance test administered to pregnant women. Pregnant women are routinely offered a 1-hour glucose challenge between 24-28 weeks gestation. Women with an abnormal result will compose the study group. A 3-hour oral glucose tolerance test will be administered without a preparatory diet. The patient will then be placed on a standard high carbohydrate diet for 3 days. Foods containing at least 150 mg of carbohydrate will be supplied to the participant, after which the glucose tolerance test will be repeated. Each patient will serve as her own control; the results of the OGTT with and without a preparatory diet will be compared. A pilot study of 20 patients will initially undergo testing. Based on these results, a sample size will be calculated.

几十年来，每天服用含有 150 克碳水化合物的预备饮食，持续三天，一直被用作诊断妊娠糖尿病的口服葡萄糖耐量试验 (OGTT) 的标准准备。 需要确认孕妇是否需要准备饮食。 避免饮食将使葡萄糖耐量测试的实施变得更简单。本研究的目的是确定预备饮食是否会显着改变孕妇的葡萄糖耐量测试结果。妊娠 24-28 周期间，孕妇通常会接受 1 小时的葡萄糖挑战。 结果异常的女性将组成研究小组。 将在不准备饮食的情况下进行 3 小时口服葡萄糖耐量测试。 然后患者将接受标准高碳水化合物饮食 3 天。 将向参与者提供至少含有 150 毫克碳水化合物的食物，然后重复葡萄糖耐量测试。 每个病人都将作为自己的对照；将比较有和没有准备饮食的 OGTT 结果。 一项针对 20 名患者的试点研究最初将接受测试。 根据这些结果，将计算样本量。