ORAL GLUCOSE TOLERANCE TEST & PREPARATORY DIET

口服葡萄糖耐量测试

• 批准号: 6309220
• 负责人: JOAN M MASTROBATTISTA
• 金额: $ 1.11万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6309220
• 关键词: clinical research; diagnosis design /evaluation; dietary carbohydrates; gestational age; gestational diabetes mellitus; glucose tolerance test; human pregnant subject; metabolism disorder diagnosis; nutrition related tag

The administration of a preparatory diet containing 150 grams of carbohydrates/day for three days has been used for decades as a standard preparation for an oral glucose tolerance test (OGTT) for the diagnosis of gestational diabetes. The need for a preparatory diet in pregnant women needs to be confirmed. Avoiding the diet will result in simpler administration of the glucose tolerance test. The objective of this study is to determine whether a preparatory diet significantly alters the results of a glucose tolerance test administered to pregnant women. Pregnant women are routinely offered a 1-hour glucose challenge between 24-28 weeks gestation. Women with an abnormal result will compose the study group. A 3-hour oral glucose tolerance test will be administered without a preparatory diet. The patient will then be placed on a standard high carbohydrate diet for 3 days. Foods containing at least 150 mg of carbohydrate will be supplied to the participant, after which the glucose tolerance test will be repeated. Each patient will serve as her own control; the results of the OGTT with and without a preparatory diet will be compared. A pilot study of 20 patients will initially undergo testing. Based on these results, a sample size will be calculated.

几十年来，作为诊断妊娠糖尿病的口服葡萄糖耐量试验（OGTT）的标准制剂，预备饮食中每天摄入150克碳水化合物，持续三天。孕妇是否需要预备饮食还有待确认。避免这种饮食会使葡萄糖耐量试验的实施更简单。本研究的目的是确定预备饮食是否会显著改变孕妇葡萄糖耐量试验的结果。在怀孕24-28周期间，孕妇通常接受1小时葡萄糖挑战。结果异常的妇女组成研究组。在没有预备饮食的情况下，进行3小时的口服葡萄糖耐量试验。然后，患者将接受标准的高碳水化合物饮食3天。参与者将获得至少含有150毫克碳水化合物的食物，之后将重复葡萄糖耐量测试。每个病人都将作为自己的对照；将对有和没有预备饮食的OGTT结果进行比较。一项针对20名患者的试点研究将首先进行测试。根据这些结果，将计算样本大小。