BIOPSYCHOSOCIAL BENEFITS OF 17 BETA ESTRADIOL IN METASTATIC CAP
17 β 雌二醇对转移帽的生物心理社会益处
基本信息
- 批准号:6231684
- 负责人:
- 金额:$ 22.22万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-09-30 至 2004-08-31
- 项目状态:已结题
- 来源:
- 关键词:behavioral /social science research tag cancer rehabilitation /care clinical research estradiol hormone therapy human subject human therapy evaluation male medical rehabilitation related tag neoplasm /cancer palliative treatment prostate neoplasms psychological aspect of cancer psychosocial rehabilitation quality of life
项目摘要
Men diagnosed with advanced prostate cancer have a median survival of about 30 months, with many patients surviving as along as 5 to 10 years. This relatively slow progression of advanced disease distinguishes prostate cancer from other common malignancies and creates a situation in which men age in the context of premature and severe male hormone deprivation due to adjuvant therapies. This hormone deprivation may well hasten mental and physical deterioration and lower the quality of life in a number of spheres. Since testosterone can be converted to estrogen, certain physical and mental effects of testosterone could reflect its peripheral conversion (via aromatase) to estradiol. Conversely, some of the negative effects of testosterone deprivation by LHRH agonists or therapeutic castration could be due to lowered levels of estradiol. Moreover, clinical and animal studies suggest psychosocial and physical health benefits from estrogen in males. It's reduction in prostate cancer patients, therefore, could contribute to their morbidity. We propose a prospective, blinded clinical trial of low-dose estradiol to test our major hypothesis that chronic, low dose oral 17-beta estradiol therapy will preserve the overall quality of life and mental, emotional, and physical health status of men maintained on treatment-related androgen deprivation. We will enroll 150 cognitively intact (Mini-Mental Status Exam score >23) metastatic prostate patients into a double-blind, placebo controlled prospective study of low-dose estrogen (17-beta micronized estradiol 0.5 mg per day) for one year. We will measure various aspects of quality of life and physical, mental, and social functioning at 10 weeks (T2), 6 months (T3) and 12 months (T4) after study entry.
诊断为晚期前列腺癌的男性的中位生存期约为30个月,许多患者存活沿着5至10年。这种进展相对缓慢的晚期疾病将前列腺癌与其他常见的恶性肿瘤区分开来,并造成了一种情况,即男性在由于辅助治疗而导致的过早和严重的男性激素剥夺的背景下衰老。这种荷尔蒙的缺乏很可能会加速精神和身体的恶化,并降低生活质量的一些领域。由于睾酮可以转化为雌激素,睾酮的某些生理和心理作用可以反映其外周转化(通过芳香酶)为雌二醇。相反,LHRH激动剂或治疗性去势剥夺睾酮的一些负面影响可能是由于雌二醇水平降低。此外,临床和动物研究表明,雌激素对男性的心理社会和身体健康有益。因此,前列腺癌患者的减少可能会导致他们的发病率。我们提出了一项低剂量雌二醇的前瞻性、盲法临床试验,以检验我们的主要假设,即长期、低剂量口服17-β雌二醇治疗将保护接受治疗相关雄激素剥夺的男性的整体生活质量和精神、情感和身体健康状况。我们将招募150名认知功能完好(简易精神状态检查评分>23)的转移性前列腺患者参加一项为期一年的低剂量雌激素(17-β微粉化雌二醇,每天0.5 mg)的双盲、安慰剂对照前瞻性研究。我们将在研究入组后10周(T2)、6个月(T3)和12个月(T4)测量生活质量和身体、心理和社会功能的各个方面。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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{{ truncateString('BERNARD A ROOS', 18)}}的其他基金
BIOPSYCHOSOCIAL BENEFITS OF 17 BETA ESTRADIOL IN METASTATIC CAP
17 β 雌二醇对转移帽的生物心理社会益处
- 批准号:
6659220 - 财政年份:2002
- 资助金额:
$ 22.22万 - 项目类别:
BIOPSYCHOSOCIAL BENEFITS OF 17 BETA ESTRADIOL IN METASTATIC CAP
17 β 雌二醇对转移帽的生物心理社会益处
- 批准号:
6501869 - 财政年份:2001
- 资助金额:
$ 22.22万 - 项目类别:
BIOPSYCHOSOCIAL BENEFITS OF 17 BETA ESTRADIOL IN METASTATIC CAP
17 β 雌二醇对转移帽的生物心理社会益处
- 批准号:
6346066 - 财政年份:2000
- 资助金额:
$ 22.22万 - 项目类别: