T CELL RECEPTOR COUPLED SIGNALING AND APOPTOSIS
T 细胞受体偶联信号传导和细胞凋亡
基本信息
- 批准号:6235317
- 负责人:
- 金额:$ 20.03万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-06-01 至 1998-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We have recently obtained evidence for a novel signalling pathway coupled
to TCR ligation by MTV superantigen an high concentrations of peptide which
leads to transient activation and apoptosis. This signalling cascade may
be associated with MAP2 kinase-dependent activation of phospholipase A2
(PLA2) and lipoxygenase which in turn catalyzes the generation of reactive
oxygen intermediates (R01s). We also outline evidence suggesting that this
pathway may regulate gene expression via activation of th p50/52 component
of the NF-kB complex. In Specific Aim 1, we propose experiments to
systematically define the kinetics of phospholipase A2 (PLA2) activation of
HPETE and release of hydroxyl radicals (OH). In Specific Aim 2, we propose
to define the proximal events which couple the TCR to PLA2 activation.
This will include an initial assessment of the role of MAP-2 kinase in PLA2
activation, followed by experimental analysis of the potential roles of p21
Ras-dependent pathways that may connect these events with TCR ligation.
Delineation of this pathway will allow us to map the interaction between
this pathway and CD28-dependent signals which inhibit the apoptotic
response following TCR ligation. In Specific Aim 3, we propose experiments
to further define the distal biochemical events which may result in
activation of NF-kB. In Specific Aim 4, we will determine whether
generation of hydroxyl radicals is necessary and sufficient for T-cell
apoptosis or whether these represent intermediates in a signalling pathway
which results in transcriptional activation of gene products responsible
for cell death.
我们最近获得了一种新的信号通路耦合的证据
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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HARVEY CANTOR其他文献
HARVEY CANTOR的其他文献
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{{ truncateString('HARVEY CANTOR', 18)}}的其他基金
Immunologic mechanisms that prevent autoimmunity
预防自身免疫的免疫机制
- 批准号:
10265652 - 财政年份:2020
- 资助金额:
$ 20.03万 - 项目类别:
Regulation of the follicular T-cell response to autoimmunity
滤泡 T 细胞对自身免疫反应的调节
- 批准号:
10066305 - 财政年份:2000
- 资助金额:
$ 20.03万 - 项目类别:
Innate cytokine responses that regulate autoimmunity
调节自身免疫的先天细胞因子反应
- 批准号:
7650695 - 财政年份:2000
- 资助金额:
$ 20.03万 - 项目类别:
Regulation of the follicular T-cell response to autoimmunity
滤泡 T 细胞对自身免疫反应的调节
- 批准号:
9199455 - 财政年份:2000
- 资助金额:
$ 20.03万 - 项目类别:
Innate cytokine responses that regulate autoimmunity
调节自身免疫的先天细胞因子反应
- 批准号:
7768461 - 财政年份:2000
- 资助金额:
$ 20.03万 - 项目类别:
Innate cytokine responses that regulate autoimmunity
调节自身免疫的先天细胞因子反应
- 批准号:
8212189 - 财政年份:2000
- 资助金额:
$ 20.03万 - 项目类别:
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