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CORE--MOLECULAR ANALYSIS OF P53 TUMOR SUPPRESSOR GENE

CORE--MOLECULAR ANALYSIS OF P53 TUMOR SUPPRESSOR GENE
核心--P53抑癌基因的分子分析
批准号：
6236715
负责人：
MARC F HANSEN
金额：
$17.91万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-08-01 至 1999-07-31
来源：
https://reporter.nih.gov/project-details/6236715
关键词：
biomedical facility denaturing gradient gel electrophoresis family genetics gene mutation genetic markers genetic polymorphism germ cells human genetic material tag method development multiple primary neoplasia neoplasm /cancer genetics nucleic acid sequence pediatric neoplasm /cancer polymerase chain reaction restriction fragment length polymorphism sarcoma southern blotting tumor suppressor genes

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英文摘要
One of the critical requirements for the success of this program will be the ability to identify heterozygous p53 mutations in the constitutional tissues of probands and their families. The foundation of this program is the examination of relatively large numbers of samples for what could be many different single base mutations. The success of this project requires the accurate and rapid identification of mutations in the p53 gene from either constitutional or tumor tissues. This core has been proposed to develop the techniques necessary to identify these mutations, and then to examine the probands or nearest affected relatives from the cohorts to determine the frequency of p53 mutations in these families and individuals.
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