IMPROVED DOSE DISTRIBUTIONS FOR CONFORMAL THERAPY

该项目的总体目标是开发、演示和 测试几种不同的技术，提高控制共形 治疗剂量分布。 目前， 保形规划通常限于几何修改（例如， 场形状和波束方向）。 最近，计算机控制的 治疗机器使（技术上）使用更多的 复杂类型的剂量分布修改技术， 从平场的静态场成形到共形场的使用 具有个体化射束强度的多叶准直射野 调变 本项目将研究光束强度的使用 调制技术，可以实现与目前可用的 计算机控制治疗机，包括计算机控制 多叶准直器（MLC）运动和计算机控制点扫描 电子束 场成形和强度调制技术将 将对它们的临床效用进行分析和比较， 在临床上使用。 该项目将大大 改善我们对剂量分布形成的控制， 交付，并将确定对灵活性的现实限制， 可通过计划设计的可输送剂量分布 优化项目（项目1）并由临床研究交付 （项目4）。

The Overall Objective of this project is to develop, demonstrate, and test several different techniques which improve control over conformal therapy dose distributions. At present, dosimetric modification of conformal plans is typically limited to geometric modification (e.g., field shape and beam directions). Recently, computer-controlled treatment machines have made possible (technically) the use of more sophisticated types of dose distribution modification techniques ranging from static field shaping of flat fields to the use of conformal multileaf-collimated fields with individualized beam intensity modulation. This project will investigate the use of beam intensity modulation techniques which can be achieved with the currently available computer-controlled treatment machines, including computer-controlled multileaf collimator (MLC) motion and computer-controlled point-scanned electron beams. Field shaping and intensity modulation techniques will be developed, their clinical utility will be analyzed and compared, and their use clinically implemented. This project will significantly improve the control we have over dose distribution formation and delivery, and will determine realistic limitations on the flexibility of deliverable dose distributions which can be designed by the plan optimization project (project 1) and delivered by the clinical study (project 4).