IMPROVED DOSE DISTRIBUTIONS FOR CONFORMAL THERAPY

该项目的总体目标是开发、演示和 测试几种改进保形控制的不同技术 治疗剂量分布。目前，剂量学修改的目的是 保形平面通常限于几何修改(例如， 场形状和波束方向)。最近，计算机控制的 治疗机器使(从技术上)使用更多的 复杂类型的剂量分布修改技术范围 从平场的静电场整形到共形的应用 具有个性化光束强度的多叶准直场 调制。这个项目将调查光束强度的使用。 利用当前可用的调制技术可以实现的 计算机控制的治疗机，包括计算机控制的 多叶准直器(MLC)运动与计算机控制点扫描 电子束。场整形和强度调制技术将 将对其临床应用进行分析和比较，并 它们的使用在临床上得到了实施。这个项目将极大地 改进我们对剂量分布形成和控制的控制 交付，并将确定对灵活性的现实限制 可按计划设计的可交付剂量分布 优化方案(方案1)，由临床研究交付 (项目4)。

The Overall Objective of this project is to develop, demonstrate, and test several different techniques which improve control over conformal therapy dose distributions. At present, dosimetric modification of conformal plans is typically limited to geometric modification (e.g., field shape and beam directions). Recently, computer-controlled treatment machines have made possible (technically) the use of more sophisticated types of dose distribution modification techniques ranging from static field shaping of flat fields to the use of conformal multileaf-collimated fields with individualized beam intensity modulation. This project will investigate the use of beam intensity modulation techniques which can be achieved with the currently available computer-controlled treatment machines, including computer-controlled multileaf collimator (MLC) motion and computer-controlled point-scanned electron beams. Field shaping and intensity modulation techniques will be developed, their clinical utility will be analyzed and compared, and their use clinically implemented. This project will significantly improve the control we have over dose distribution formation and delivery, and will determine realistic limitations on the flexibility of deliverable dose distributions which can be designed by the plan optimization project (project 1) and delivered by the clinical study (project 4).