COMMUNITY REINFORCEMENT APPROACH & NALTREXONE FOR OPIOID DEPENDENCE
社区强化方法
基本信息
- 批准号:6237983
- 负责人:
- 金额:$ 23.72万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-07-01 至 1998-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
There is increasing consensus that outcomes for substance abuse treatment
can be enhanced and extended with the addition of psychosocial approach.
The disappointing record of naltrexone, an excellent, long acting opioid
antagonist, in the substance abuse treatment system, may in part be due
to failure to combine it with psychosocial approaches to enhance
compliance with naltexone and reward abstinence.
The multifaceted CRA approach developed by Higgins and colleagues is
particularly attractive as a strategy to improve outcomes in naltraxone
treatment because several of its components could be targeted to
directly address naltrexone's weakness. For example, to compensate for
naltrexone's lack of pharmacological reward, contingency management
through use of a voucher system could be used to reward and enhance
naltrexone ingestion. Similarly, involvement of significant others in
treatment through reciprocal relationship counseling could be used to
provide increased incentives for retention and encouragement to persist
with treatment despite protracted withdrawal. Using a dismantling
strategy, we will evaluate the value of adding these two distinct
components of Higgins' treatment package to standard naltrexone
maintenance.
180 recently detoxified opioid addicts will be randomly assigned to
either (1) contingency management plus significant other involvement in
addition to standard naltrexone treatment, (2) contingency management
in addition to standard naltrexone treatment, or (3) standard naltrexone
treatment alone, consisting of thrice weekly clinic visits for
naltrexone, thrice weekly supervised urine toxicology screens, and weekly
group counseling. Primary outcomes will be retention, compliance with
naltraxone treatment, and reduction in opioid, cocaine, and other
substance use. All treatments will be manual-guided and delivered by
experienced clinicians, who will receive training and ongoing supervision
to prevent drift during the course of the study. Supervised urines will
be collected thrice weekly. All counseling sessions will be videotaped
for ongoing therapist supervision and process assessment. Follow-ups
conducted 3, 6, 9 and 12 months after the cessation of the contingency
management and relationship counseling will assess the durability of
treatment effects.
越来越多的人认为药物滥用治疗的结果
可以通过增加心理社会方法来加强和扩展。
纳洛酮令人失望的记录,一种优秀的长效阿片类药物
药物滥用治疗系统中的拮抗剂,可能部分是由于
未能将其与心理社会方法结合起来,
依从纳得酮并奖励禁欲。
希金斯及其同事开发的多方面CRA方法是
作为改善纳曲酮治疗结果的策略,
治疗,因为它的几个组成部分可以针对
直接解决纳洛酮的弱点 例如补偿
纳洛酮缺乏药理学奖励,应急管理
通过使用代金券系统,可以用来奖励和提高
纳洛酮摄入。 同样,重要他人的参与
通过互惠关系咨询的治疗可以用来
提供更多的激励措施,以留住人才,并鼓励坚持下去
尽管长期戒断, 使用拆解
战略,我们将评估增加这两个不同的价值
Higgins治疗包的组成部分与标准纳洛酮
上维护
180名最近戒毒的阿片类药物成瘾者将被随机分配到
(1)应急管理加上其他重要参与,
除了标准纳曲酮治疗外,(2)应急管理
除标准纳洛酮治疗外,或(3)标准纳洛酮
单独治疗,包括每周三次门诊访视,
纳洛酮,每周三次监督尿液毒理学筛查,
团体咨询 主要结局将是保留率、依从性
纳曲酮治疗,减少阿片类药物、可卡因和其他
物质使用。 所有治疗都将由人工指导,
经验丰富的临床医生,他们将接受培训和持续监督
以防止在研究过程中发生漂移。 受监督的尿液将
每周收集三次。 所有的咨询过程都会被录像
进行治疗师监督和过程评估。 随访
在应急措施停止后3、6、9和12个月进行
管理和关系咨询将评估持久性
治疗效果
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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KATHLEEN CARROLL其他文献
KATHLEEN CARROLL的其他文献
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{{ truncateString('KATHLEEN CARROLL', 18)}}的其他基金
Engaging & treating young court referred marijuana users
引人入胜
- 批准号:
6660509 - 财政年份:2002
- 资助金额:
$ 23.72万 - 项目类别:
Engaging & treating young court referred marijuana users
引人入胜
- 批准号:
6495093 - 财政年份:2001
- 资助金额:
$ 23.72万 - 项目类别:
Engaging & treating young court referred marijuana users
引人入胜
- 批准号:
6356523 - 财政年份:2000
- 资助金额:
$ 23.72万 - 项目类别:
Engaging & treating young court referred marijuana users
引人入胜
- 批准号:
6349029 - 财政年份:2000
- 资助金额:
$ 23.72万 - 项目类别:
COMMUNITY REINFORCEMENT APPROACH & NALTREXONE FOR OPIOID DEPENDENCE
社区强化方法
- 批准号:
6104087 - 财政年份:1998
- 资助金额:
$ 23.72万 - 项目类别:
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