CENTER OF EXCELLENCE FOR MATERIALS SCIENCE RESEARCH

材料科学研究卓越中心

• 批准号: 2545655
• 负责人: RAFAEL LEE BOWEN
• 金额: $ 65.33万
• 依托单位: AMERICAN DENTAL ASSOCIATION FOUNDATION
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-29 至 1999-09-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2545655
• 关键词: biomaterial development /preparation; biomaterial evaluation; dental materials

Research proposed herein by the American Dental Association Health Foundation (ADAHF) is intended to (1) provide new and improved biocompatible dental restorative materials as alternatives to dental amalgam; (2) develop a coating that will improve the efficacy of currently-placed amalgam restorations; (3) develop appropriate clinical instrumentation, procedures and guidelines for the successful use of these materials; and (4) develop innovating materials processing strategies and facilitate the transfer of these technologies to dental manufacturers and practicing dentists. This interrelated, multidisciplinary research is responsive to the PHS "Healthy People 2000" agenda; to the goals of Specialized Materials Science Research Centers, as stated in RFA DE-93-001; and to a major initiative by the National Institute of Dental Research to develop improved, economical and biocompatible alternatives to dental amalgam. In testimony before the House Appropriations Subcommittee in March 1993, Dr. Harald Loe reported the development of a "prototype mercury-free dental amalgam." The material to which he referred was invented by scientists at the National Institute of Standards and Technology (NIST) and its viability was demonstrated in a pilot project of the ADAHF's Center of Excellence for Materials Science Research. Some phases of the material's further development are now being conducted by Center staff in collaboration with NIST scientists, and continued work on this project is proposed in this application (Consolidation and Delivery Methods for a Metallic Direct- filling Amalgam Alternative). It is also proposed that the Center research team that developed glass-ceramic inserts to improve the properties of composite restorations, introduced commercially in 1991, investigate other applications of the glass-ceramic material (Glass- ceramic Restorative Materials). It is proposed that current Center research to develop protective tooth coatings be extended to the development of polymeric coatings adhesive not only to crown and root surfaces but also to restorations of amalgam and its alternative materials (Polymers for Preventive Coatings and Margin Repairs); that current Center work on expanding monomers be redirected toward a general investigation of stress reduction in composite restorations (Reduction of Polymerization Shrinkage and Stress); and that the "synthetic dentin" being developed by Center staff be further explored for a variety of dental and biocompatability testing applications (Novel Adhesive Cariostatic Cements).

由美国牙科协会健康研究所提出的研究 基金会（ADAHF）旨在（1）提供新的和改进的 生物相容性牙科修复材料作为牙科替代品 汞合金;（2）开发一种涂层， 目前放置的银汞合金;（3）制定适当的临床 仪器，程序和指南，以成功地使用 这些材料;（4）开发创新的材料加工 战略和促进这些技术转移到牙科 制造商和执业牙医。 这种相互关联的， 多学科研究是对公共卫生系统“2000年健康人”的响应 议程;专业材料科学研究中心的目标， 如RFA DE-93-001所述;以及国家 牙科研究所开发改进的，经济的， 牙科汞合金的生物相容性替代品。 在听证会上， 1993年3月，众议院拨款小组委员会，Harald Loe博士报告说， 开发“无汞牙科汞合金原型”。“那 他提到的材料是由国家科学院的科学家发明的。 标准与技术研究所（NIST）及其可行性 在ADAHF卓越中心的一个试点项目中， 材料科学研究。 材料的某些相进一步 目前，中心工作人员正在与 NIST的科学家，并继续在这个项目上的工作提出了这一建议， 应用（金属直接运输的合并和交付方法） 填充汞齐替代品）。 还建议该中心 研究团队开发了玻璃陶瓷插入物，以改善 1991年商业上引入的复合材料的性能， 研究玻璃陶瓷材料的其他应用（玻璃- 陶瓷修复材料）。 建议目前中心 保护牙齿涂层的研究将扩展到 聚合物涂层的发展不仅对冠和根粘合 表面，而且也适用于汞合金及其替代品 材料（用于防护涂层和边缘修补的聚合物）; 目前中心在扩大单体方面的工作应转向一般的 复合材料减应力研究 聚合收缩和应力）;并且“合成牙本质” 正在开发的中心工作人员将进一步探讨各种 牙科和生物相容性测试应用（新型粘合剂 防龋水泥）。