POLYMERS FOR PREVENTIVE COATINGS AND MARGIN REPAIRS

用于预防性涂层和边缘修复的聚合物

• 批准号: 6104793
• 负责人: RAFAEL LEE BOWEN
• 金额: $ 7.17万
• 依托单位: AMERICAN DENTAL ASSOCIATION FOUNDATION
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-29 至 1999-09-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6104793
• 关键词: biomaterial development /preparation; biomaterial evaluation; dental adhesive /sealant; dental caries inhibitor; dental materials; human tissue; polymers; preventive dentistry

The long term objectives and specific aims are to improve and broaden the scope of state-of-the-art technology for preparation and utilization of durable adhesive resin coatings that can form thin, polymeric films on tooth crowns and roots and fill minor defects in restorative materials. The purposes for clinical applications of these novel formulations are numerous: to protect intact enamel and to infiltrate "white spots," thereby arresting further demineralization; to protect exposed dentin from caries development; to relive "hypersensitivity" and shield the underlying pulp from damage; to obturate contraction gaps commonly found in gingival portions of composite restorations; to fill notches at the margins of otherwise sound, existing amalgam restorations; to close and seal areas of imperfect margins of inlays, crowns and bridges due to loss of luting agents for prevention of secondary caries; and to fill microscopic cracks and small voids on adjusted and finished surfaces of ceramic and composite restorations. The protocol will provide for removal of plaque and pellicle from tooth surfaces and gaps around existing restorations, wetting and penetration of these debrided surfaces by capillary action with the coating resin formulations, and rapid and thorough polymerization by a novel dual-cure system. The materials and methods will build upon information gained in recent and contemporary studies but will go beyond previous aims, as indicated above. The experimental design will consist of formulation of monomers and polymers that incorporate new components together with some that have already been found to promote adhesion to dentin, enamel, amalgam, precious and semiprecious alloys, and ceramic surfaces. Procedures will evaluate strategies for polymerization of these formulations as thin protective coatings and for resistance to dislodgement and abrasion under challenging conditions simulating those in oral cavities; appropriately modified ASTM and other test methods (for surface coatings designed for adverse environments) will be used. Both the designs of experiments and data analyses will be aided by the SAS program and consultations with expert NIST statisticians. The methods will make use of thin film formation on freshly extracted teeth obtained from local dentists and oral surgeons and some of the restorative materials listed above.

长期目标和具体目标是改善和扩大 最新技术的范围 耐用的粘合剂树脂涂层，其可在 牙冠和牙根，并填充修复材料中的微小缺陷。 这些新制剂的临床应用目的是 许多：保护完整的牙釉质和渗透"白色斑点"， 从而阻止进一步的脱矿作用;保护暴露的牙本质 从龋齿发展;重温"超敏反应"和屏蔽 下面的牙髓损伤;封闭收缩间隙常见的 在复合牙列的牙龈部分;以填充 其他方面健全的现有汞合金 因缺失而导致的嵌体、牙冠和牙桥边缘不完美的密封区域 预防继发性龋齿的粘合剂;以及 调整和抛光表面上的微观裂纹和小空隙， 陶瓷和复合材料。 协议将规定： 从牙齿表面和周围间隙去除牙菌斑和表膜 这些清创表面的现有润湿、润湿和渗透 通过与涂料树脂制剂的毛细管作用， 通过新型双固化体系使聚合彻底。 的材料和 方法将建立在最近和当代获得的信息基础上， 研究，但将超越以前的目标，如上所述。 的 实验设计将包括单体和聚合物的配方 它将新的组成部分与一些已经被 发现可促进对牙本质、牙釉质、汞合金、贵重金属和 半贵重合金和陶瓷表面。 程序将评估 聚合这些制剂作为薄保护剂的策略 涂层，并用于耐下移位和磨损 模拟口腔中的挑战性条件;适当 修改的ASTM和其他测试方法（适用于 恶劣的环境下使用。 实验设计和 数据分析将得到SAS程序的帮助， NIST统计专家。 这些方法将利用薄膜 从当地牙医那里获得的新拔牙的牙齿上的形成， 口腔外科医生和上面列出的一些修复材料。